Flow-based stereoselective reduction of ketones using an immobilized ketoreductase/glucose dehydrogenase mixed bed system

Articolo
Data di Pubblicazione:
2017
Citazione:
Flow-based stereoselective reduction of ketones using an immobilized ketoreductase/glucose dehydrogenase mixed bed system / F. Dall'Oglio, M.L. Contente, P. Conti, F. Molinari, D. Monfredi, A. Pinto, D. Romano, D. Ubiali, L. Tamborini, I. Serra. - In: CATALYSIS COMMUNICATIONS. - ISSN 1566-7367. - 93:(2017), pp. 29-32. [10.1016/j.catcom.2017.01.025]
Abstract:
A robust two-enzyme system composed of an immobilized ketoreductase (KRED1-Pglu) and a glucose dehydrogenase (BmGDH) was developed via immobilization on aldehyde agarose for the stereoselective reduction of different ketones. The immobilized ketoreductase/glucose dehydrogenase system was continuously used in a flow reactor for weeks, even in the presence of concentrations of DMSO up to 20%.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Biocatalysis; Ketoreductase; Enantioselective reduction; Flow reactor; Immobilization
Elenco autori:
F. Dall'Oglio, M.L. Contente, P. Conti, F. Molinari, D. Monfredi, A. Pinto, D. Romano, D. Ubiali, L. Tamborini, I. Serra
Autori di Ateneo:
CONTENTE MARTINA LETIZIA ( autore )
CONTI PAOLA ( autore )
MOLINARI FRANCESCO ENZO ( autore )
PINTO ANDREA ( autore )
ROMANO DIEGO ( autore )
TAMBORINI LUCIA ( autore )
Link alla scheda completa:
https://air.unimi.it/handle/2434/500030
Link al Full Text:

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