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Innovative functional foods based on sweet lupin protein for cardiovascular prevention

Project


Period 31/Oct/2011-31/March/2014. Grant og the UMIl team: 344000 per RTD activities and 43000 for coordination.
The objective is to assess the health benefits on dislipidemia prevention of innovative food products based on lupin proteins, starting from some preliminary results provided by 2 past European collaborative projects (Healthy-Profood & Bioprofibre). The core RTD activity is the implementation of a multicenter randomized dietary intervention study with LDL-cholesterol as main end-point aimed to compare the hypolipidemic effect of lupin proteins vs. animal proteins. Besides LDL-Cholesterol other inflammatory and metabolic markers will be investigated. In addition the metabolism of cholesterol will be analysed. All these data will be exploited at the end of the project by the submission of an application to the European Commission for the approval a health claim on lupin and cholesterol reduction. The project will include also product development and optimization, with particular reference to the nutrition profiles of the foods. Specific activities will be dedicaer questo motivo alcuneted to assess the quality of the lupin proteins in the food products. Innovation activities will be dedicated also to the application of a “New Concept Development” for new products, new services and new markets for enterprises. To reach these objectives the LUPICARP consortium includes 5 food producing SMEs, 1 lupin ingredient manufacturer and 5 RTD performers expert in product innovation, food processing, clinical nutrition, pharmacology. Efficient technology transfer will be ensured to improve the competitiveness of participating SMEs.

  • Overview
  • Research Areas
  • Publications

Overview

Contributors (4)

CALABRESI LAURA   Participant  
LAMMI CARMEN   Participant  
MAGNI PAOLO   Participant  
RUSCICA MASSIMILIANO   Participant  

Type

7PQCP-CSA - 7 Programma Quadro_Collaborative Project/Network/Coordination and Support Action

Funder

EUROPEAN COMMISSION
External Organization Funding Organization

Date/time interval

October 1, 2011 - March 31, 2014

Project duration

30 months

Research Areas

Concepts (3)


10.86 - Produzione di preparati omogeneizzati e di alimenti dietetici

72.11 - Ricerca e sviluppo sperimentale nel campo delle biotecnologie

LS9_6 - Food sciences - (2013)

Keywords (9)

  • ascending
  • descending
CARDIOVASCULAR DISEASE
DISLIPIDEMIA
LUPIN SEED
LUPINO
MALATTIE CARDIOVASCOLARI
NUTRACEUTICA
NUTRACEUTICS
PLANT PROTEIN
PROTEINE VEGETALI
No Results Found
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Publications

Outputs (8)

Investigations on the hypocholesterolaemic activity of LILPKHSDAD and LTFPGSAED, two peptides from lupin β-conglutin : focus on LDLR and PCSK9 pathways 
JOURNAL OF FUNCTIONAL FOODS
ELSEVIER
2017
Academic Article
Partially Open Access
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A multidisciplinary investigation on the bioavailability and activity of peptides from lupin protein 
JOURNAL OF FUNCTIONAL FOODS
ELSEVIER
2016
Academic Article
Reserved Access
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Hypocholesterolaemic Activity of Lupin Peptides : Investigation on the Crosstalk between Human Enterocytes and Hepatocytes Using a Co-Culture System Including Caco-2 and HepG2 Cells 
NUTRIENTS
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI)
2016
Academic Article
Open Access
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Lupin protein exerts cholesterol-lowering effects targeting PCSK9: from clinical evidences to elucidation of the in vitro molecular mechanism using HepG2 cells 
JOURNAL OF FUNCTIONAL FOODS
ELSEVIER LTD
2016
Academic Article
Open Access
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A simple and high-throughput in-cell Western assay using HepG2 cell line for investigating the potential hypocholesterolemic effects of food components and nutraceutics 
FOOD CHEMISTRY
ELSEVIER
2015
Academic Article
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The role of grain legumes in the prevention of hypercholesterolemia and hypertension 
CRITICAL REVIEWS IN PLANT SCIENCES
TAYLOR & FRANCIS
2015
Academic Article
Reserved Access
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Three Peptides from Soy Glycinin Modulate Glucose Metabolism in Human Hepatic HepG2 Cells 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2015
Academic Article
Open Access
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Lupin Peptides Lower Low-Density Lipoprotein (LDL) Cholesterol through an Up-regulation of the LDL Receptor/Sterol Regulatory Element Binding Protein 2 (SREBP2) Pathway at HepG2 Cell Line 
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
AMERICAN CHEMICAL SOCIETY
2014
Academic Article
Open Access
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