Chemoenzymatic deacylation of ramoplanin

Articolo
Data di Pubblicazione:
2012
Citazione:
Chemoenzymatic deacylation of ramoplanin / R. Gandolfi, F. Marinelli, E. Ragg, D. Romano, F. Molinari. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 22:16(2012), pp. 5283-5287.
Abstract:
The chemoenzymatic deacylation of ramoplanin A2 is described for the first time: ramoplanin A2 was Boc-protected and hydrogenated to Boc-protected tetrahydroramoplanin, which was subsequently deacylated using an acylase from Actinoplanes utahensis NRRL 12052. The chemoenzymatic process proceeded with 80% overall yield, which favourably compares with the previously described chemical deacylation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Ramoplanin; Antibiotics; Biotransformation; Acylase; Actinoplanes utahensis
Elenco autori:
R. Gandolfi, F. Marinelli, E. Ragg, D. Romano, F. Molinari
Autori di Ateneo:
GANDOLFI RAFFAELLA ( autore )
MOLINARI FRANCESCO ENZO ( autore )
ROMANO DIEGO ( autore )
Link alla scheda completa:
https://air.unimi.it/handle/2434/199758