Data di Pubblicazione:
2019
Citazione:
Stereoselective Reduction of Prochiral Cyclic 1,3-Diketones Using Different Biocatalysts / M.L. Contente, F. Dall'Oglio, F. Annunziata, F. Molinari, M. Rabuffetti, D. Romano, L. Tamborini, D. Rother, A. Pinto. - In: CATALYSIS LETTERS. - ISSN 1011-372X. - (2019). [Epub ahead of print]
Abstract:
We have developed biocatalytic methods for the stereoselective reduction of cyclic prochiral 1,3-diketones for the production of optically active β-hydroxyketones and/or 1,3-diols. The recombinant ketoreductase KRED1-Pglu (formulated as purified catalyst) and whole cells of wild type Escherichia coli DE3 Star were used as biocatalysts, displaying different and sometimes complementary stereoselectivity, thus allowing the preparation of stereochemically pure β-hydroxyketones (12–66% isolated yields, > 99% e.e.) and 1,3-diols (40–60% isolated yields, > 99% e.e.).
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
1,3-Diols; 1-3 diketones; Biocatalytic reduction; Enzymatic; Whole cells; β-hydroxyketones
Elenco autori:
M.L. Contente, F. Dall'Oglio, F. Annunziata, F. Molinari, M. Rabuffetti, D. Romano, L. Tamborini, D. Rother, A. Pinto
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