Bioprocess Intensification Using Flow Reactors: Stereoselective Oxidation of Achiral 1,3-diols with Immobilized Acetobacter Aceti
Articolo
Data di Pubblicazione:
2019
Citazione:
Bioprocess Intensification Using Flow Reactors: Stereoselective Oxidation of Achiral 1,3-diols with Immobilized Acetobacter Aceti / V. DE VITIS, F. Dall'Oglio, F. Tentori, M.L. Contente, D. Romano, E. Brenna, L. Tamborini, F.E. Molinari. - In: CATALYSTS. - ISSN 2073-4344. - 9:3(2019 Mar). [10.3390/catal9030208]
Abstract:
Enantiomerically enriched 2-hydroxymethylalkanoic acids were prepared by oxidative desymmetrisation of achiral 1,3-diols using immobilized cells of Acetobacter aceti in water at 28 ◦C. The biotransformations were first performed in batch mode with cells immobilized in dry alginate, furnishing the desired products with high molar conversion and reaction times ranging from 2 to 6 h. The biocatalytic process was intensified using a multiphasic flow reactor, where a segmented gas–liquid flow regime was applied for achieving an efficient O2-liquid transfer; the continuous flow systems allowed for high yields and high biocatalyst productivity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
oxidation; whole cells; immobilization; biocatalysis; flow reactor; reactor design
Elenco autori:
V. DE VITIS, F. Dall'Oglio, F. Tentori, M.L. Contente, D. Romano, E. Brenna, L. Tamborini, F.E. Molinari
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