Enantioselective reduction and deracemisation using the non-conventional yeast Pichia glucozyma in water-organic solvent biphasic systems : preparation of (S)-1,2-diaryl-2-hydroxyethanones (benzoins)
Articolo
Data di Pubblicazione:
2012
Citazione:
Enantioselective reduction and deracemisation using the non-conventional yeast Pichia glucozyma in water-organic solvent biphasic systems : preparation of (S)-1,2-diaryl-2-hydroxyethanones (benzoins) / M. C. Fragnelli, P. Hoyos, D. Romano, R. Gandolfi, A. R. Alcántara, F. Molinari. - In: TETRAHEDRON. - ISSN 0040-4020. - 68:2(2012 Jan), pp. 523-528. [10.1016/j.tet.2011.11.014]
Abstract:
Water/organic solvent two-liquid-phase systems have been successfully applied in the synthesis of enantiomerically pure (S)-benzoin through two different methodologies catalysed by whole cells from the non-conventional yeast Pichia glucozyma: the stereoselective monoreduction of benzil and the deracemisation of benzoin. The presence of the organic solvent influences the redox systems implied in the reactions, avoiding the formation of the corresponding diols, increasing the enantioselectivity and allowing the easy isolation of the products in high yields and excellent enantiomeric excesses. The use of both strategies has been extended to the preparation of different chiral benzoin derivatives.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Benzoin ; Deracemisation ; Pichia glucozyma ; Benzil ; Dehydrogenase ; Stereoselective reduction ; Two-liquid-phase system
Elenco autori:
M.C. Fragnelli, P. Hoyos, D. Romano, R. Gandolfi, A.R. Alcántara, F. Molinari
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