Effect of (Poly)phenols on Lipid and Glucose Metabolisms in 3T3-L1 Adipocytes: an Integrated Analysis of Mechanistic Approaches

Purpose of Review: This systematic review aims to elucidate the effects of (poly)phenols (PPs) on mature 3T3-L1 adipocytes via the regulation of lipid and glucose metabolism. Recent Findings: PPs can modulate glucose uptake, reduce intracellular lipid content and enhance lipolytic activity in mature 3T3-L1 adipocytes. These effects are mediated through changes at both gene expression level (e.g. Ppara and Sirt1) and protein level (e.g. activation of AMPK and adiponectin levels). However, there is no consensus on the concentrations at which PPs exert their anti-lipogenic activity, and it remains unclear whether different PPs activate distinct molecular pathways. Summary: PPs are a diverse group of plant-derived secondary metabolites with recognized anti-obesogenic potential. While their inhibitory effects on adipogenesis are well established, their role in modulating lipid metabolism in fully differentiated adipocytes remains less well understood. Emerging evidence from studies on mature 3T3-L1 adipocytes indicates that PPs can influence key metabolic processes, including lipid storage and mobilization. These findings highlight the potential of PPs as modulators of adipose tissue metabolism, while also emphasizing the need for translational research to clarify their mechanisms of action and therapeutic efficacy in vivo.