Data di Pubblicazione:
2009
Citazione:
Asymmetric reductions of ethyl 2-(benzamidomethyl)-3-oxobutanoate by yeasts / R. Gandolfi, E. Cesarotti, F.E. Molinari, D. Romano, I. Rimoldi. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 20:4(2009), pp. 411-414. [10.1016/j.tetasy.2009.02.023]
Abstract:
The stereoselective reduction of ethyl 2–(benzamidomethyl)-3-oxobutanoate 1 using yeasts was investigated among a restricted number (12) of yeasts. Kluyveromyces marxianus var. lactis CL69 diastereoselectively produced (2R,3S)-ethyl 2–(benzamidomethyl)-3- hydroxybutanoate 2, whereas Pichia glucozyma CBS 5766 gave (2S,3S)-2 as the major stereoisomer. The biotransformations were independently optimised for minimizing by-products formation and maximizing the diastereoselectivity. . Under optimised conditions, K. marxianus var lactis CL 69 gave the (2R,3S)-ethyl 2–(benzamidomethyl)-3-hydroxybutanoate 2 with e.e. > 99% and d.e. = 98%, while P. glucozyma CBS 5766 allowed for the obtainment of (2S,3S)-2 with e.e. > 99% and d.e. = 86%.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Gandolfi, E. Cesarotti, F.E. Molinari, D. Romano, I. Rimoldi
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