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Biomechanics in health and disease: advanced physical tools for innovative early diagnosis (Phys2BioMed)

Project
Phys2BioMed will offer excellent interdisciplinary and cross-sectoral training to a team of motivated early stage researchers (ESRs) on the application of cutting-edge physical tools for the mechanical phenotyping of cells and tissues of clinical relevance, aiming at developing novel early-diagnostic tools. The Phys2BioMed network will
merge diverse competences at European level, from different fields like nanoscience and nanotechnology, physics,
biology, and medicine, and will expose ESRs to the non academic and private sector. A key element of the project
is the peer-to-peer collaboration of research academic institutions with industries and world-leading medical and
clinical centers; these are the main actors of the global challenge against diseases, and within Phys2BioMed they
will highlight unmet clinical needs, and actively cooperate with academic colleagues for developing novel diagnostic
strategies. ESRs will be trained-through-research by world-leading junior and senior PIs, and will benefit of lecture
courses, dedicated international schools and workshops, and topical conferences. Secondments to other nodes of the
network will represent the main and more effective channel of dissemination and cross-fertilization of competences,
ideas, and knowledge within the network. Besides training talented young scientists, ready to work at the boundary of
diverse disciplines in the field of nanomedicine, Phys2BioMed will provide scientific and technological outcomes on
biomechanics, and the mechanical determinants of diseases. Technology-wise, it will define standardized procedures
for nanomechanical measurements, and the definition of the main features of new-generation instrumentation
optimized for the mechanical phenotyping of clinical specimens. In the longer-term, Phys2BioMed will provide
the platform and know-how to build a data bank of mechanical fingerprints of diseases, setting the ground for the
development of effective early-diagnostic tools.,Phys2BioMed will offer excellent interdisciplinary and cross-sectoral training to a team of motivated early stage researchers (ESRs) on the application of cutting-edge physical tools for the mechanical phenotyping of cells and tissues of clinical relevance, aiming at developing novel early-diagnostic tools. The Phys2BioMed network will merge diverse competences at European level, from different fields like nanoscience and nanotechnology, physics, biology, and medicine, and will expose ESRs to the non academic and private sector. A key element of the project is the peer-to-peer collaboration of research academic institutions with industries and world-leading medical and clinical centers; these are the main actors of the global challenge against diseases, and within Phys2BioMed they will highlight unmet clinical needs, and actively cooperate with academic colleagues for developing novel diagnostic strategies. ESRs will be trained-through-research by world-leading junior and senior PIs, and will benefit of lecture courses, dedicated international schools and workshops, and topical conferences. Secondments to other nodes of the network will represent the main and more effective channel of dissemination and cross-fertilization of competences, ideas, and knowledge within the network. Besides training talented young scientists, ready to work at the boundary of diverse disciplines in the field of nanomedicine, Phys2BioMed will provide scientific and technological outcomes on biomechanics, and the mechanical determinants of diseases. Technology-wise, it will define standardized procedures for nanomechanical measurements, and the definition of the main features of new-generation instrumentation optimized for the mechanical phenotyping of clinical specimens. In the longer-term, Phys2BioMed will provide the platform and know-how to build a data bank of mechanical fingerprints of diseases, setting the ground for the development of effective early-diagnostic tools.
  • Overview
  • Publications
  • Contacts

Overview

Contributors

PODESTA' ALESSANDRO MARIO GIACOMO   Scientific Manager  

Departments involved

Dipartimento di Fisica Aldo Pontremoli   Principale  

Type

H20MCITNIF - Horizon 2020_Marie Skłodowska-Curie actions-Innovative Training Network (ITN)/Individual Fellowships (IF)

Funder

EUROPEAN COMMISSION
External Organization Funding Organization

Date/time interval

January 1, 2019 - December 31, 2022

Project duration

48 months

Publications

Outputs (20)

  • ascending
  • descending
  • All
  • Academic Article
  • Chapter
  • Edited Book
Progressive alteration of murine bladder elasticity in actinic cystitis detected by Brillouin microscopy 
SCIENTIFIC REPORTS
NATURE RESEARCH
2024
Academic Article
Open Access
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Correlation between biological and mechanical properties of extracellular matrix from colorectal peritoneal metastases in human tissues 
SCIENTIFIC REPORTS
NATURE PUBLISHING GROUP
2023
Academic Article
Open Access
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Decellularized extracellular matrix as scaffold for cancer organoid cultures of colorectal peritoneal metastases 
JOURNAL OF MOLECULAR CELL BIOLOGY
OXFORD ACADEMIC
2023
Academic Article
Open Access
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Micro-mechanical fingerprints of the rat bladder change in actinic cystitis and tumor presence 
COMMUNICATIONS BIOLOGY
NATURE
2023
Academic Article
Open Access
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Native extracellular matrix probes to target patient- and tissue-specific cell-microenvironment interactions by force spectroscopy 
NANOSCALE
THE ROYAL SOCIETY OF CHEMISTRY
2023
Academic Article
Open Access
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Reliable, standardized measurements for cell mechanical properties 
NANOSCALE
ROYAL SOCIETY OF CHEMISTRY
2023
Academic Article
Open Access
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Decellularized Normal and Tumor Extracellular Matrix as Scaffold for Cancer Organoid Cultures of Colorectal Peritoneal Metastases 
2022
Academic Article
Open Access
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Force Sensing on Cells and Tissues by Atomic Force Microscopy 
SENSORS
MDPI
2022
Academic Article
Open Access
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Force sensing on cells and tissues by atomic force microscopy 
2022
Academic Article
Open Access
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Interaction of imidazolium-based ionic liquids with supported phospholipid bilayers as model biomembranes 
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
ROYAL SOCIETY OF CHEMISTRY
2022
Academic Article
Reserved Access
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The glycocalyx affects the mechanotransductive perception of the topographical microenvironment 
JOURNAL OF NANOBIOTECHNOLOGY
2022
Academic Article
Open Access
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Large colloidal probes for atomic force microscopy : fabrication and calibration issues 
JOURNAL OF MOLECULAR RECOGNITION
WILEY
2021
Academic Article
Open Access
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Stiffening of DU145 prostate cancer cells driven by actin filaments-microtubule crosstalk conferring resistance to microtubule-targeting drugs 
NANOSCALE
ROYAL SOCIETY OF CHEMISTRY
2021
Academic Article
Partially Open Access
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The glycocalyx affects force loading-dependent mechanotransductive topography sensing at the nanoscale 
2021
Academic Article
Open Access
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Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level 
NANOSCALE
ROYAL SOCIETY OF CHEMISTRY
2020
Academic Article
Partially Open Access
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AFM Calibration Issues 
DE GRUYTER STEM
DE GRUYTER
2023
Chapter
Reserved Access
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AFM Cantilevers and Tips 
DE GRUYTER STEM
DE GRUYTER
2023
Chapter
Reserved Access
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Contact Mechanics 
DE GRUYTER STEM
DE GRUYTER
2023
Chapter
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Mechanics of Cells and Tissues in Diseases. Volume 2. Biomedical Applications 
DE GRUYTER
2023
Edited Book
Reserved Access
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Mechanics of Cells and Tissues in Diseases: Biomedical Methods: Volume 1 
DE GRUYTER STEM
DE GRUYTER
2023
Edited Book
Reserved Access
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Contacts

Web site

https://www.phys2biomed.eu/
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