NR-NET is a multidisciplinary consortium, whose activities are directed towards the understanding of the role of Nuclear
Receptors (NRs) and coregulators in metaflammatory disease. Metaflammation - metabolic disorders linked to chronic
inflammation ¿ is an emerging concept explaining the pathogenesis of a wide-spectrum of diseases. Since several
nuclear receptors can directly sense metabolic alterations, we propose that they could be considered as important
endogenous modulators of metaflammatory pathways further expanding the repertoire of diseases that can be intervened by
NR-modulating drugs.
NR-NET is expected to deliver important new knowledge on the basic biological processes involved in the mechanism of
epigenetic control of gene expression by nuclear receptors, on structural and functional aspects of nuclear receptor action
with an ultimate goal of better understanding the pathogenesis of metabolic disorders and inflammation.
The composition of the network was designed to contain a balanced mix of labs with experience and skills in academic and
industry based research, so that it can provide young researchers the opportunity to acquire skills and expertise in:
a. Structural and functional aspects of NR-regulated gene expression
b. Genomics and proteomics approaches to analyze complex regulatory networks
c. Systems biology approaches and bioinformatics tools to define composite regulatory modules
d. Studying metabolic and inflammatory pathways in model organisms
The research will be conducted under the framework of a structured training program, which includes a myriad of Individual
and Network-wide training activities. Apart from training in academic and industry-based research projects, specific emphasis
will be given to training in transferable skills and the stimulation of creativity and entrepreneurial mindset of researchers.