PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular Metabolism
Articolo
Data di Pubblicazione:
2021
Citazione:
PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular Metabolism / L. Coppi, S. Ligorio, N. Mitro, D. Caruso, E.S.R. De Fabiani, M. Crestani. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 22:13(2021 Jun 27), pp. 6913.1-6913.11. [10.3390/ijms22136913]
Abstract:
Metabolism is the central engine of living organisms as it provides energy and building
blocks for many essential components of each cell, which are required for specific functions in different
tissues. Mitochondria are the main site for energy production in living organisms and they also
provide intermediate metabolites required for the synthesis of other biologically relevant molecules.
Such cellular processes are finely tuned at different levels, including allosteric regulation, posttranslational
modifications, and transcription of genes encoding key proteins in metabolic pathways.
Peroxisome proliferator activated receptor ! coactivator 1 (PGC1) proteins are transcriptional coactivators
involved in the regulation of many cellular processes, mostly ascribable to metabolic pathways.
Here, we will discuss some aspects of the cellular processes regulated by PGC1s, bringing up some
examples of their role in mitochondrial and cellular metabolism, and how metabolic regulation in
mitochondria by members of the PGC1 family affects the immune system. We will analyze how PGC1
proteins are regulated at the transcriptional and posttranslational level and will also examine other
regulators of mitochondrial metabolism and the related cellular functions, considering approaches
to identify novel mitochondrial regulators and their role in physiology and disease. Finally, we
will analyze possible therapeutical perspectives currently under assessment that are applicable to
different disease states.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
mitochondria; metabolic regulation; mitochondrial disorders
Elenco autori:
L. Coppi, S. Ligorio, N. Mitro, D.M. Caruso, E.S.R. DE FABIANI, M. Crestani
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