VENTURIN MARCO

NAME, PLACE AND DATE OF BIRTH
VENTURIN Marco
Milan, 23/06/1973

POSITION
Associate Professor of Applied Biology (BIO/13) (since 2020)

EDUCATION/TRAINING
1999 M.Sc. Biology (University of Milan), field: genomics
2004 Ph.D. Neurology, Psychiatry and Neurogenetics (University of Genoa), field: molecular genetics
2006 Master in Bioinformatics (University of Turin), field: bioinformatics, comparative genomics

POSITIONS AND EMPLOYMENT
2004-2005 Postdoctoral Fellow, University of Milan
2006-2019 Assistant Professor of Applied Biology, University of Milan

OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS
2000 1st Bioinformatics Course, European School of Genetic Medicine (European Genetics Foundation sponsored Fellowship)
2003 (Jul-Sept) EMBO Short Term Fellowship, EMBL Computational Biology Unit, Heidelberg, Germany
2005-present Member of Italian Association of Biology and Genetics (AIBG)
2009-2017 Board of training scientists, Ph.D. School in Biological and Molecular Sciences/Cellular and Molecular Biology (University of Milan)
2014 (Sept) Visiting scientist at CIBIO (Centre for Integrative Biology) of University of Trento in the Laboratory of RNA Biology and Biotechnology (director: dr. Michela A. Denti)

RESEARCH SUPPORT
RBFR-0895DC, FIRB (Basic Research Investment Fund) 2008 Grant - MIUR (Italian Ministry of Education, University and Research)
Title: Mechanisms of post-transcriptional regulation of gene expression in dementias
Project duration: 4 years (12/01/2010-11/30/2014)
Role in the project: Scientific coordinator of the Research Unit 2 (University of Milan)
Amount: € 168.200

Research Support Grant 2015, Dept. BioMeTra, University of Milan
Title: The role of transcriptional and post-transcriptional regulation of CDK5R1 expression in aging and Alzheimer’s disease
Project duration: 1 year (01/01/2016-12/3/2016)
Role in the project: Principal Investigator
Amount: € 18.000

Italian Moebius Syndrome Association
Title: Mutation analysis of PLXND1 and REV3L genes in patients with Moebius syndrome
Project duration: 2 years
Role in the project: Principal Investigator
Amount: € 17.000

Research Support Grant 2020, Dept. BioMeTra, University of Milan
Title: Investigation of non-coding RNAs and their targets potentially associated to autophagy in
aging and senescence
Project duration: 1 year
Role in the project: Co-Principal Investigator
Amount: € 20.000

Seal of Excellence (SoE) SEED 2020, University of Milan
Title: Impariamo dagli antenati: la metamorfosi dei Tunicati come modello di neurodegenerazione –
IMPATTO
Project duration: 1 year
Role in the project: Scientific coordinator of the Research Unit 2
Amount: € 30.000

TEACHING
- Bachelor programmes: Medical Biotechnologies (Bioinformatics, Molecular and cellular
methodologies), Nursing (Basic Sciences), Exercise Sciences, Sports and Health (Biology, Chemistry
and General Biochemistry)
- Master programmes: Medical Biotechnology and Molecular Medicine (Genetic and molecular bases
of diseases)
- Specialisation Schools: Medical Genetics (Database for medical genetics)

RESEARCH ACTIVITY
- Mechanisms of regulation of gene expression mediated by non-coding RNAs (miRNAs, lncRNAs) and their possible involvement in aging and in the pathogenesis of neurodegenerative diseases.
- Genetic basis underlying Intellectual Disability and rare syndromes

PUBLICATIONS
32 publications in peer-reviewed journals (7 as a first, 8 as last/corresponding author)
h-index (Scopus) = 15
h-index (Google Scholar) = 18

LAST 10 PUBLICATIONS
Casiraghi V., Sorce M.N., Santangelo S., Invernizzi S., Bossolasco P., Lattuada C., Battaglia C.,
Venturin M., Silani V., Colombrita C., Ratti A. Modeling of TDP-43 proteinopathy by chronic
oxidative stress identifies rapamycin as beneficial in ALS patient-derived 2D and 3D iPSC
models. Exp Neurol, 2024. Epub ahead of print.

Frediani E., Anceschi C., Ruzzolini J., Ristori S., Nerini A., Laurenzana A., Chillà A., Germiniani
C.E.Z., Fibbi G., Del Rosso M., Mocali A., Venturin M., Battaglia C., Giovannelli L., Margheri F.
Divergent regulation of long non-coding RNAs H19 and PURPL affects cell senescence in human
dermal fibroblasts. Geroscience, 2024. Epub ahead of print.

Moresco G., Bedeschi M.F., Venturin M., Villa R., Costanza J., Mauri A., Santaniello C., Picciolini
O., Messina L., Triulzi F., Miozzo M.R., Rondinone O., Fontana L. - Exploring the Impact of
Genetics in a Large Cohort of Moebius Patients by Trio Whole Exome Sequencing. Genes (Basel),
15(8):971, 2024.

Rossi C., Venturin M., Gubala J., Frasca A., Corsini A., Battaglia C. and Bellosta S. - PURPL and
NEAT1 Long Non-Coding RNAs Are Modulated in Vascular Smooth Muscle Cell Replicative
Senescence. Biomedicines, 11(12):3228, 2023.

Consiglio A.*, Venturin M.*, Briguglio S., Rossi C., Grillo G., Bellosta S., Cattaneo M.G., Licciulli
F. and Battaglia C. - Lost in HELLS: Disentangling the mystery of SALNR existence in senescence
cellular models. PLoS ONE, 18(5):e0286104, 2023.

Rusconi F., Battaglioli E. and Venturin M. - Psychiatric disorders and lncRNAs: a synaptic
match. Review. Int J Mol Sci, 21(9): E3030, 2020.

Battaglia C., Venturin M., Sojic A., Jesuthasan N., Orro A., Spinelli R., Musicco M., De Bellis G.
and Adorni F. - Candidate genes and miRNAs linked to the inverse relationship between cancer
and Alzheimer’s disease: insights from data mining and enrichment analysis. Front Genet,
10:846, 2019.

Riva P., Battaglia C. and Venturin M. - Emerging role of genetic alterations affecting exosome
biology in neurodegenerative diseases. Review. Int J Mol Sci, 20(17): E4113, 2019.
Spreafico M., Grillo B., Rusconi F., Battaglioli E. and Venturin M. - Multiple layers of CDK5R1
regulation in Alzheimer's disease implicate long non-coding RNAs. Int J Mol Sci, 19(7): E2022,
2018.

Moncini S., Lunghi M., Valmadre A., Grasso M., Del Vescovo V., Riva P., Denti M.A. and Venturin
M. - The miR-15/107 family of microRNA genes regulates CDK5R1/p35 with implications for
Alzheimer’s disease pathogenesis. Mol Neurobiol, 54: 4329-4342, 2017.