ROTA PAOLA

New strategies in the treatment of ischemic diseases. - Drug design and synthesis of NEU3 membrane sialidase inhibitors and modulators. - Development of new GM3 synthase inhibitors. - Synthesis of small molecules belonging to different classes of hypoxia-inducible factor 1α (HIF1α) prolyl hydroxylase-2 (PHD2) inhibitors. (2015 - )

Studies on the role played by sialic acid derivatives in the biological systems and their involvement in various pathologies. - Synthesis and analysis of sialic acid carbohydrate family finalized to understand the biochemistry of these sugars better. - Design and synthesis of some inhibitors against viral neuraminidases. - As a remarkable result in this field, we found compounds with 5- to 15-fold greater potency than the currently most active compound on specific viral neuraminidase. (2007 - )