Synthesis of γ-glutamyl derivatives of sulfur-containing amino acids in a multigram scale via a two-step, one-pot procedure
Articolo
Data di Pubblicazione:
2020
Citazione:
Synthesis of γ-glutamyl derivatives of sulfur-containing amino acids in a multigram scale via a two-step, one-pot procedure / G. Speranza, M. Rabuffetti, N. Vidovic, C.F. Morelli. - In: MOLBANK. - ISSN 1422-8599. - 2020:3(2020 Jul), pp. M1147.1-M1147.8.
Abstract:
γ-Glutamyl derivatives of sulfur amino acids have been prepared in multigram scale starting from readily available starting materials. The synthesis comprises two one-pot operations, both consisting of two reactions. In the first operation, N-phtaloyl-l-glutamic acid anhydride is obtained from l-glutamic acid and phtalic anhydride. In the second one, N-phtaloyl-l-glutamic acid anhydride is used to acylate amino acids and the N-phtaloyl protecting group is removed. The described approach offers a viable entry to γ-glutamyl derivatives of sulfur-containing amino acids with flavor-enhancer and nutraceutical properties.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Kokumi; One-pot synthesis; Sulfur amino acids; Taste-active compounds; γ-glutamyl compounds
Elenco autori:
G. Speranza, M. Rabuffetti, N. Vidovic, C.F. Morelli
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