Data di Pubblicazione:
2003
Citazione:
Clustering of tuberculosis among Senegalese immigrants in Italy / A. Matteelli, A. Gori, G. Pinsi, I. El-Hamad, E. Bombana, F. Mastaglia, A. Esposti, A. Bandera, S. Tedoldi, C. Casalini, C. Scolari, A. Carvalho, G. Carosi. - In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. - ISSN 1027-3719. - 7:10(2003), pp. 967-972.
Abstract:
OBJECTIVE: To study clustered Mycobacterium tuberculosis isolates as an indicator of recent TB transmission in a small urban setting in Italy, and to determine associated risk factors.
METHODS: M. tuberculosis strains isolated between 1991 and 1997 were characterised by IS6110 restriction fragment length polymorphism (RFLP) analysis.
RESULTS: One hundred and ninety-five isolates were available for RFLP analysis, which revealed 163 different patterns. Available cases were represented by 137 Italians (70%), 32 Senegalese (17%), and 26 other foreign-born cases (13%). A unique fingerprint pattern was found in 143 cases (73.3 %), while 52 strains (26.7%) were grouped into 20 clusters. Nineteen cases (10%) were resident in the same quarter of Brescia with a high density of Senegalese immigrants (Area A). An increased probability of yielding clustered M. tuberculosis strains was associated with residence in Area A (OR 3.87, 95% CI 1.42-10.56; P = 0.02) and being Senegalese (OR = 5.96,95% CI 1.48-23.97; P = 0.005). In the logistic regression analysis, being Senegalese was independently associated with yielding a clustered M. tuberculosis strain.
CONCLUSIONS: Our results demonstrate a clustering of TB cases among Senegalese immigrants and suggest that RFLP analysis may be used to identify geographical areas where efforts can be targeted to interrupt TB transmission.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
tuberculosis; immigrants; RFLP
Elenco autori:
A. Matteelli, A. Gori, G. Pinsi, I. El-Hamad, E. Bombana, F. Mastaglia, A. Esposti, A. Bandera, S. Tedoldi, C. Casalini, C. Scolari, A. Carvalho, G. Carosi
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