Data di Pubblicazione:
2018
Citazione:
Hyperthermia properties of gold fiducial markers / S. Gallo, P. Arosio, M. Avolio, L. Bonizzoni, M. Cobianchi, M. Gargano, N. Ludwig, F. Orsini, I. Veronese. - In: PHYSICA MEDICA. - ISSN 1120-1797. - 56:Supplement 2(2018 Dec 20), pp. 261.222-261.223. ((Intervento presentato al 10. convegno National Congress of the Associazione Italiana di Fisica Medica tenutosi a Bari nel 2018 [10.1016/j.ejmp.2018.04.271].
Abstract:
Purpose. The combination of Radiotherapy and Magnetic Fluid
Hyperthermia (MFH) is gaining importance since it may offer new
strategies for several oncological pathologies. In MFH magnetic
nanoparticles are injected directly into the tumour and, under the
action of an externally applied alternating magnetic field HAC, they
generate an amount of heat proportional to the field. Metallic materials implanted within 40 cm from the tumour heat up during MFH
treatment and are removed. The aim of this work is to investigate the
hyperthermia properties of the fiducial markers employed in Image
Guided Radiation Therapy (IGRT) and to study the physics mechanisms of the observed macroscopic effects.
Methods and materials. Hydrogel matrix samples were prepared
and used as tissue mimicking materials. Different types of gold fiducial markers used in IGRT procedures were positioned in gel samples,
considering various geometric configurations simulating the actual
position of the markers in the clinical practice. Hyperthermic properties of gold fiducial markers were studied varying the field amplitude HAC from 7 to 17 kA/m and the frequency from 100 to 1000
kHz. During the stimulation, an optical fiber based sensor enables
the measurement of the temperature in a point of the hydrogel samples. Beside these temperature measurement, a high-resolution thermal camera was used to map the temperature distribution over the
samples.
Results. Preliminary results attested an increase of the temperature in the gel matrices as effect of the heating of the gold fiducial
markers under a suitable magnetic stimulation. Hyperthermic
effects were also significant in the typical experimental conditions
(2 < HAC < 15 kA/m and f = 100 kHz) employed at present in MFH
clinical trials.
Conclusion. The results of this study highlight the need to carefully
evaluate the presence and location of gold fiducial markers in
patients undergoing MFH treatments, in order to prevent damage
to health tissues surrounding the lesions.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. Gallo, P. Arosio, M. Avolio, L. Bonizzoni, M. Cobianchi, M. Gargano, N. Ludwig, F. Orsini, I. Veronese
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