Cascade Reaction by Chemo- and Biocatalytic Approaches to Obtain Chiral Hydroxy Ketones and anti 1,3-Diols

Achemo- andbiocatalytic cascade approach was applied for the stereos
elective synthesis of hydroxy ketone
sand the corresponding 1,3-diols. A new class of tridentate N,N,Oligands
was used with coppe r(II) complexes for the asymmetric b-borylation of a, b-unsaturated compounds. The complex containing ligand L5 emergedas the best performer,and it gave the orga-noborane derivatives with good ee values.
The corresponding keto–alcohol compounds were then bioreduced by yeasts. The biotransformation
set up with Rhodo Torula rubra allowed (R)- keto– alcohols and (S, S)-diols to be obtained with up to 99% ee and up to 99% de in favor of the anti enantiomers.