MiRNA’s profiling and primary graft dysfunction: novel non-invasive biomarkers

Lung transplantation is a clinica reality but survival rates are still improving. In this scenario primary graft dysfunction (PGD) is the major cause of mortality in the first 30 days after lung tranplantation and its pathogenesis remains poorly understood. MicroRNAs are ubiquitous regulators of human biology and emerging evidence indicates microRNA expression modulates disease processes. We aimed to identify microRNAs biomarker of PGD and their contribution in the PGD pathogenesis.