Immunosuppressive therapy in pancreas and islet transplant : Need for simultaneous assessment of insulin sensitivity and secretion

Diabetes mellitus is a metabolic disease possi- ble to treat via pancreas/islet transplantation but most immunosuppressive drugs are diabeto- genic. In this letter, we review current up to date methods to assess insulin action and secretion (using the surrogate indexes) suggesting their use in large studies in populations of pancreas/ islets transplanted patients.