Effects of endurance exercise training on metabolic and inflammatory parameters in HIV-1-infected patients with secondary lipodystrophy and diabetes

Regular physical exercise exerts positive effects, prolonging survival and improving quality of life of HIV-1-infected patients. A 3-month supervised endurance training program in subjects with AIDS-related lipodystrophy and type 2 diabetes mellitus improved aerobic capacity, pancreatic beta-cell function and immune profile, with a reduction in the proinflammatory cytokines monocyte chemotactic protein-1 and tumor necrosis factor-alpha. Appropriate physical exercise combined with specific pharmacological and dietetic therapies could prevent the development of secondary metabolic and cardiovascular disorders.