SYNTHESIS OF ISOTHIOCYANATES BY REACTION OF AMIDES WITH CARBON-DISULFIDE IN THE PRESENCE OF SOLID POTASSIUM CARBONATE SODIUM-HYDROXIDE MIXTURE

Readily available N-monosubstituted trifluoroacetamides are transformed into isothiocyanates in good yield by reaction, at room temperature, with carbon disulfide in acetonitrile in the presence of anhydrous sodium hydroxide/potassium carbonate basic mixture.