TETRABUTYLAMMONIUM DIHYDROGENTRIFLUORIDE AS A POWERFUL CATALYST IN THE REGIOSELECTIVE OPENING OF EPOXIDES WITH ACTIVATED AROMATIC AND HETEROAROMATIC CHLORIDES

Tetrabutylammonium dihydrogentrifluoride, Bu(4)N(+)H(2)F(3)(-), was found to be a very efficient catalyst in the ring opening of epoxides by aromatic or heteroaromatic chlorides to prepare the corresponding 2-aryloxy- or 2-heteroaryloxy-1-chloroalkyl derivatives 8 in 62-87% yield, by operating at 90 degrees C without solvent.