Biological performance of a novel biodegradable polyamidoamine hydrogel as guide for peripheral nerve regeneration
Articolo
Data di Pubblicazione:
2011
Citazione:
Biological performance of a novel biodegradable polyamidoamine hydrogel as guide for peripheral nerve regeneration / V. Magnaghi, V. Conte, P. Procacci, G. Pivato, P.D. Cortese, E.M. Cavalli, G.E. Pajardi, E. Ranucci, F. Fenili, A.G. Manfredi, P. Ferruti. - In: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A. - ISSN 1549-3296. - 98:1(2011), pp. 19-30.
Abstract:
Polyamidoamines (PAAs) are a well-known family of synthetic biocompatible and biodegradable polymers, which can be prepared as soft hydrogels characterized by
low interfacial tension and tunable elasticity. For the first time we report here on the in vivo performance of a PAA
hydrogel implant as scaffold for tissue engineering. In particular, an amphoteric agmatine-deriving PAA hydrogel shaped as small tubing was obtained by radical polymerization of a soluble functional oligomeric precursor and used as conduit
for nerve regeneration in a rat sciatic nerve cut model. The animals were analyzed at 30, 90, and 180 days post-surgery.
PAA tubing proved to facilitate nerve regeneration. Good surgical outcomes were achieved with no signs of inflammation
or neuroma. Moreover, nerve regeneration was morphologically sound and the quality of functional recovery satisfactory.
In conclusion, PAA hydrogel scaffolds may represent a novel and promising material for peripheral nerve regeneration.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
biodegradation; hydrogel; nerve guide; polyamidoamine; sciatic nerve
Elenco autori:
V. Magnaghi, V. Conte, P. Procacci, G. Pivato, P.D. Cortese, E.M. Cavalli, G.E. Pajardi, E. Ranucci, F. Fenili, A.G. Manfredi, P. Ferruti
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