Ferrocene Derivatives Supported on Poly(N-Vinylpyrrolidin-2-one) (PVP) : Synthesis of New Water Soluble Electrochemically Active Probes for Biomolecules
Articolo
Data di Pubblicazione:
2007
Citazione:
Ferrocene Derivatives Supported on Poly(N-Vinylpyrrolidin-2-one) (PVP) : Synthesis of New Water Soluble Electrochemically Active Probes for Biomolecules / C. Baldoli, C. Oldani, E. Licandro, P. Ramani, A. Valerio, P. Ferruti, L. Falciola, P. Mussini. - In: JOURNAL OF ORGANOMETALLIC CHEMISTRY. - ISSN 0022-328X. - 692:6(2007), pp. 1363-1371.
Abstract:
Carboxy-terminated polyvinylpyrrolidin-2-one (PVP) has been used as a new water-soluble and biocompatible polymeric support for a series of ferrocene-labeled amino acid and peptide nucleic acid (PNA) monomer derivatives 4-7. The organometallic polymer-conjugates thus obtained are new and potentially useful as water-soluble electrochemically active probes for biomolecules. In view of such application, their electrochemical activity has been evaluated and has proved very high notwithstanding the complexity and bulkiness of the molecule, affording detection limits down to 10-8 M in the aqueous medium.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bioorganometallic chemistry ; Ferrocene ; Functionalized PVP ; Electrochemically active probes ; Polymer conjugation
Elenco autori:
C. Baldoli, C. Oldani, E. Licandro, P. Ramani, A. Valerio, P. Ferruti, L. Falciola, P. Mussini
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