TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology
Articolo
Data di Pubblicazione:
2023
Citazione:
TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology / A. Ort, J.W. Smallridge, S. Sarasso, S. Casarotto, R. von Rotz, A. Casanova, E. Seifritz, K.H. Preller, G. Tononi, F.X. Vollenweider. - In: ISCIENCE. - ISSN 2589-0042. - 26:5(2023 May 19), pp. 106589.1-106589.12. [10.1016/j.isci.2023.106589]
Abstract:
Exploring the neurobiology of the profound changes in consciousness induced by classical psychedelic drugs may require novel neuroimaging methods. Serotonergic psychedelic drugs such as psilocybin produce states of increased sensory-emotional awareness and arousal, accompanied by increased spontaneous electroencephalographic (EEG) signal diversity. By directly stimulating cortical tissue, the altered dynamics and propagation of the evoked EEG activity can reveal drug-induced changes in the overall brain state. We combine Transcranial Magnetic Stimulation (TMS) and EEG to reveal that psilocybin produces a state of increased chaotic brain activity which is not a result of altered complexity in the underlying causal interactions between brain regions. We also map the regional effects of psilocybin on TMS-evoked activity and identify changes in frontal brain structures that may be associated with the phenomenology of psychedelic experiences.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Clinical neuroscience; Medical imaging; Pharmacology
Elenco autori:
A. Ort, J.W. Smallridge, S. Sarasso, S. Casarotto, R. von Rotz, A. Casanova, E. Seifritz, K.H. Preller, G. Tononi, F.X. Vollenweider
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