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  1. Attività

Human Brain Project Specific Grant Agreement 3 (HBP SGA3)

Progetto
The last of four multi-year work plans will take the HBP to the end of its original incarnation as an EU Future and Emerging Technology Flagship. The plan is that the end of the Flagship will see the start of a new, enduring European scientific research infrastructure, EBRAINS, hopefully on the European Strategy Forum on Research Infrastructures (ESFRI) roadmap. The SGA3 work plan builds on the strong scientific foundations laid in the preceding phases, makes structural adaptations to profit from lessons learned along the way (e.g. transforming the previous Subprojects and Co-Design Projects into fewer, stronger, well-integrated Work Packages) and introduces new participants, with additional capabilities. The SGA3 work plan is built around improved integration and a sharpening of focus, to ensure a strong HBP legacy at the end of this last SGA. In previous phases, the HBP laid the foundation for empowering empirical and theoretical neuroscience to approaching the different spatial and temporal scales using state-of-the-art neuroinformatics, simulation, neuromorphic computing, neurorobotics, as well as high-performance analytics and computing. While these disciplines have been evolving for some years, we now see a convergence in this field and a dramatic speedingup of progress. Data is driving a scientific revolution that relies heavily on computing to analyse data and to provide the results to the research community. Only with strong computer support, is it possible to translate information into knowledge, into a deeper understanding of brain organisation and diseases, and into technological innovation. In this respect, the underlying Fenix HPC and data e-infrastructure, co-designed with the HBP, will be key. The services offered by EBRAINS will be grouped in six Service Categories: SC1: Curated and shared data: EBRAINS FAIR data services - neuroscience data publishing SC2: Brain atlas services: navigate the brain in 3D - find, contribute and analyse brain data, based on location SC3: Brain modelling and simulation workflows: integrated tools to create and investigate models of the brain SC4: Closed loop AI and robotics workflows: design, test and implement robotic and AI solutions SC5: Medical brain activity data platform: human intracerebral EEG database and analysis service SC6: Interactive workflows on HPC or NMC: Europe-wide access to scalable and interactive compute services Their users are to be supported with High-Level Support Teams and Vouchers, as well as Engagement and Facility Hubs located around Europe, at which additional services, unique equipment and compute infrastructure will be offered by local HBP Partners. Significant outcomes in relevant scientific communities are expected to materialise rapidly. Association with new Partnering Projects is still sought, along with wider international cooperation. The SGA3 objectives can be summarised as: 1) Establish a sustainable European scientific research infrastructure, EBRAINS, leading to an increased use and adoption of FAIR data, web-based analyses, model building, simulation, atlasing, and virtual experiments for brain research and brain-inspired sciences. 2) Provide a multi-level atlas of the human brain - the first of its kind that links microstructural detail and inter-subject variability. 3) Increase the capacity of neuroscientists for multiscale neural activity modelling of the human brain network. 4) Increase the availability of integrated multiscale data and computational models supporting brain states transitions, network complexity and cognitive functions.
  • Dati Generali
  • Aree Di Ricerca
  • Pubblicazioni

Dati Generali

Partecipanti

MASSIMINI MARCELLO   Responsabile scientifico  

Dipartimenti coinvolti

Dipartimento di Scienze Biomediche e Cliniche   Principale  

Tipo

H20_RIA - Horizon 2020_Research & Innovation Action/Innovation Action

Finanziatore

EUROPEAN COMMISSION
Organizzazione Esterna Ente Finanziatore

Capofila

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE - EPFL

Periodo di attività

Aprile 1, 2020 - Marzo 31, 2023

Durata progetto

36 mesi

Aree Di Ricerca

Settori


Settore BIO/09 - Fisiologia

Pubblicazioni

Pubblicazioni (17)

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Control of cortical slow oscillations and epileptiform discharges with photoswitchable type 1 muscarinic ligands 
PNAS NEXUS
NATIONAL ACADEMY OF SCIENCES
2025
Articolo
Open Access
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Assessing mismatch negativity (MMN) and P3b within-individual sensitivity - A comparison between the local-global paradigm and two specialized oddball sequences 
EUROPEAN JOURNAL OF NEUROSCIENCE
WILEY ONLINE LIBRARY
2024
Articolo
Open Access
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Investigating the Impact of Local Manipulations on Spontaneous and Evoked Brain Complexity Indices: A Large-Scale Computational Model 
APPLIED SCIENCES
MDPI
2024
Articolo
Open Access
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Photoswitchable Carbamazepine Analogs for Non-Invasive Neuroinhibition In Vivo 
ANGEWANDTE CHEMIE. INTERNATIONAL EDITION
WILEY BLACKWELL PUBLISHING : GERMAN CHEMICAL SOCIETY (GDCH)
2024
Articolo
Open Access
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Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group 
NEUROCRITICAL CARE
SPRINGER NATURE
2023
Articolo
Reserved Access
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Detecting cortical reactivity alterations induced by structural disconnection in subcortical stroke 
CLINICAL NEUROPHYSIOLOGY
ELSEVIER
2023
Articolo
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TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology 
ISCIENCE
CELL PRESS ELSEVIER INC.
2023
Articolo
Open Access
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The maturation of aperiodic EEG activity across development reveals a progressive differentiation of wakefulness from sleep 
NEUROIMAGE
ELSEVIER
2023
Articolo
Open Access
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Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients 
BRAIN STRUCTURE AND FUNCTION
SPRINGER
2022
Articolo
Open Access
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EEG spectral exponent as a synthetic index for the longitudinal assessment of stroke recovery 
CLINICAL NEUROPHYSIOLOGY
ELSEVIER
2022
Articolo
Open Access
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Multiple Poses and Thermodynamics of Ligands Targeting Protein Surfaces: The Case of Furosemide Binding to mitoNEET in Aqueous Solution 
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
FRONTIERS MEDIA S.A.
2022
Articolo
Open Access
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Probing cortical structural integrity after focal hemorrhagic stroke: A TMS-EEG case 
CLINICAL NEUROPHYSIOLOGY
ELSEVIER IRELAND LTD
2022
Articolo
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TAAC - TMS Adaptable Auditory Control: A universal tool to mask TMS clicks 
JOURNAL OF NEUROSCIENCE METHODS
ELSEVIER
2022
Articolo
Open Access
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The role of neuronavigation in TMS-EEG studies : Current applications and future perspectives 
JOURNAL OF NEUROSCIENCE METHODS
ELSEVIER
2022
Articolo
Open Access
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Consciousness and complexity: a consilience of evidence 
NEUROSCIENCE OF CONSCIOUSNESS
OXFORD ACADEMIC
2021
Articolo
Open Access
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Tonic somatosensory responses and deficits of tactile awareness converge in the parietal operculum 
BRAIN
2021
Articolo
Open Access
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Are There Islands of Awareness? 
TRENDS IN NEUROSCIENCES
ELSEVIER
2020
Articolo
Open Access
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