2-O-Acetyl-3,4,5,6-tetra-O-benzyl-d-myo-inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
Articolo
Data di Pubblicazione:
2022
Citazione:
2-O-Acetyl-3,4,5,6-tetra-O-benzyl-d-myo-inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids / S. Sangiorgio, M. Cambò, R. Semproli, D. Ubiali, G. Speranza, M. Rabuffetti. - In: CHIRALITY. - ISSN 0899-0042. - 34:8(2022 Aug), pp. 1038-1043. [10.1002/chir.23457]
Abstract:
Inositol phosphates and inositol phospholipids are ubiquitous in biochemistry and play a central role in cell signaling and regulation events. For this reason, their synthesis has attracted widespread interest. This paper describes the preparation of a new optically active inositol phosphate derivative, 2-O-acetyl-3,4,5,6-tetra-O-benzyl-d-myo-inosityl diphenylphosphate (6), and its characterization by spectroscopic methods. Compound (6) represents a useful intermediate for the preparation of inositol phosphate and phospholipids, in particular of glycerophosphoinositol (GPI), a natural anti-inflammatory agent.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
anti-inflammatory activity; desymmetrization; l-camphor dimethyl acetal; myo-inositol phosphate; myo-inositol phospholipids
Elenco autori:
S. Sangiorgio, M. Cambò, R. Semproli, D. Ubiali, G. Speranza, M. Rabuffetti
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