Data di Pubblicazione:
2022
Citazione:
5-(4-Nitrophenyl)furan-2-carboxylic Acid / M. Mori, A. Tresoldi, S. Villa, G. Cazzaniga, M. Bellinzoni, F. Meneghetti. - In: MOLBANK. - ISSN 1422-8599. - 2022:4(2022 Dec 02), pp. M1515.1-M1515.9. [10.3390/M1515]
Abstract:
The ever-evolving research in the field of antitubercular agents has led to the identification
of several new potential drug classes. Among them, 5-phenyl-furan-2-carboxylic acids have emerged
as innovative potential therapeutics, targeting iron acquisition in mycobacterial species. In our efforts
to characterize the molecular interactions between these compounds and their protein target (MbtI
from M. tuberculosis) by means of co-crystallization experiments, we unexpectedly obtained the
structure of 5-(4-nitrophenyl)furan-2-carboxylic acid (1). Herein, we describe the preparation of the
compound and its analysis by 1H NMR, 13C NMR, HRMS, and SC-XRD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
furan; SC-XRD; synchrotron; Mycobacterium tuberculosis; antitubercular agent; iron acquisition; MbtI;
Elenco autori:
M. Mori, A. Tresoldi, S. Villa, G. Cazzaniga, M. Bellinzoni, F. Meneghetti
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