Dietary Polyphenols and In Vitro Intestinal Fructose Uptake and Transport: A Systematic Literature Review
Articolo
Data di Pubblicazione:
2022
Citazione:
Dietary Polyphenols and In Vitro Intestinal Fructose Uptake and Transport: A Systematic Literature Review / S. Iametti, F. Bonomi, M. DI NUNZIO. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:(2022 Nov 18), pp. 14355.1-14355.19. [10.3390/ijms232214355]
Abstract:
Recent evidence links chronic consumption of large amounts of fructose (FRU) with sev-
eral non-communicable disease. After ingestion, dietary FRU is absorbed into the intestinal tract by
glucose transporter (GLUT) 5 and transported to the portal vein via GLUT2. GLUT2 is primarily
localized on the basolateral membrane, but GLUT2 may be dislocated post-prandially from the ba-
solateral membrane of intestinal cells to the apical one. Polyphenols (PP) are plant secondary me-
tabolites that exert hypoglycemic properties by modulating intracellular insulin signaling pathways
and by inhibiting intestinal enzymes and transporters. Post-prandially, PP may reach high concen-
trations in the gut lumen, making the inhibition of FRU absorption a prime target for exploring the
effects of PP on FRU metabolism. Herein, we have systematically reviewed studies on the effect of
PP and PP-rich products on FRU uptake and transport in intestinal cells. In spite of expectations,
the very different experimental conditions in the various individual studies do not allow definitive
conclusions to be drawn. Future investigations should rely on standardized conditions in order to
obtain comparable results that allow a credible rating of polyphenols and polyphenol-rich products
as inhibitors of fructose uptake.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
polyphenols; fructose; uptake; transport; intestinal cells
Elenco autori:
S. Iametti, F. Bonomi, M. DI NUNZIO
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