Role of Berry Anthocyanins and Phenolic Acids on Cell Migration and Angiogenesis : an Updated Overview
Articolo
Data di Pubblicazione:
2019
Citazione:
Role of Berry Anthocyanins and Phenolic Acids on Cell Migration and Angiogenesis : an Updated Overview / P. Tsakiroglou, N.E. Vandenakker, C. Del Bo', P. Riso, D. Klimis-Zacas. - In: NUTRIENTS. - ISSN 2072-6643. - 11:5(2019 May 15), pp. 1075.1-1075.11. [10.3390/nu11051075]
Abstract:
Cell migration is a critical process that is highly involved with normal and pathological
conditions such as angiogenesis and wound healing. Important members of the RHO GTPase family
are capable of controlling cytoskeleton conformation and altering motility characteristics of cells.
There is a well-known relationship between small GTPases and the PI3K/AKT pathway. Endothelial
cell migration can lead to angiogenesis, which is highly linked to wound healing processes. Phenolics,
flavonoids, and anthocyanins are major groups of phytochemicals and are abundant in many
natural products. Their antioxidant, antimicrobial, anti-inflammatory, antidiabetic, angiogenenic,
neuroprotective, hepatoprotective, and cardioprotective properties have been extensively documented.
This comprehensive review focuses on the in vitro and in vivo role of berry extracts and single
anthocyanin and phenolic acid compounds on cell migration and angiogenesis. We aim to summarize
the most recent published studies focusing on the experimental model, type of berry extract, source,
dose/concentration and overall eect(s) of berry extracts, anthocyanins, and phenolic acids on the
above processes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cell migration; angiogenesis; anthocyanins; phenolic acids; berries; extracts; polyphenols; HUVEC
Elenco autori:
P. Tsakiroglou, N.E. Vandenakker, C. Del Bo', P. Riso, D. Klimis-Zacas
Link alla scheda completa: