Data di Pubblicazione:
2018
Citazione:
Iron status in dogs with myxomatous mitral valve disease / A. Savarese, M. Probo, C. Locatelli, A.L. Gazzonis, S.A. Zanzani, G. Traini, T. Vitiello, P.G. Brambilla. - In: POLISH JOURNAL OF VETERINARY SCIENCES. - ISSN 1505-1773. - 21:3(2018), pp. 507-515.
Abstract:
In humans, iron deficiency represents a relevant occurrence in heart failure (HF), with or
without anaemia, and is associated with the worst outcome. Moreover, chronic kidney disease
(CKD) is a well-known comorbidity of HF and is strongly associated with the risk of developing
anaemia. The most common cause of HF in dogs is myxomatous mitral valve disease (MMVD).
To the best of our knowledge, no studies have examined the iron status in dogs with HF, with and
without CKD. The aim of this retrospective study was to evaluate the iron status in dogs affected
by MMVD and how strong is the relation with HF.
The retrospective study included 54 dogs with complete case records, echocardiography and
laboratory analyses. Iron status was evaluated by measuring serum iron concentration (SIC), unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), and percentage of
saturation (%SAT).
The prevalence of dogs showing low serum iron concentration (SIC) was 18% in the whole
population, 33% in symptomatic patients, 100% in dogs with acute decompensated HF. No significant differences in SIC, UIBC, TIBC and %SAT median values were found among dogs classified in different ACVIM (American College of Veterinary Internal Medicine) classes, between
symptomatic and non-symptomatic patients, and among IRIS (International Renal Interest Society) classes. Azotemic and non-azotemic patients presented a significant difference in SIC mean
values (p=0.02). Generalised linear model (GLM) revealed that dogs with low SIC were at higher risk of being included in a higher ACVIM class (OR=6.383, p-value=0.014).
Log-rank analysis showed shorter survival in dogs with low SIC (p=0.020), multivariate Cox
analysis revealed that only HF symptoms can affect survival.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
iron; dog; myxomatous mitral valve disease; cardiorenal syndrome; cardiovascular-renal disorder
Elenco autori:
A. Savarese, M. Probo, C. Locatelli, A.L. Gazzonis, S.A. Zanzani, G. Traini, T. Vitiello, P.G. Brambilla
Link alla scheda completa:
Link al Full Text: