Cascade Reaction by Chemo- and Biocatalytic Approaches to Obtain Chiral Hydroxy Ketones and anti 1,3-Diols
Articolo
Data di Pubblicazione:
2018
Citazione:
Cascade Reaction by Chemo- and Biocatalytic Approaches to Obtain Chiral Hydroxy Ketones and anti 1,3-Diols / R. Gandolfi, G. Facchetti, M. Christodoulou, M. Fusè, F. Meneghetti, I. Rimoldi. - In: CHEMISTRYOPEN. - ISSN 2191-1363. - 7:(2018 May 25), pp. 393-400. [10.1002/open.201800056]
Abstract:
Achemo- andbiocatalytic cascade approach was applied for the stereos
elective synthesis of hydroxy ketone
sand the corresponding 1,3-diols. A new class of tridentate N,N,Oligands
was used with coppe r(II) complexes for the asymmetric b-borylation of a, b-unsaturated compounds. The complex containing ligand L5 emergedas the best performer,and it gave the orga-noborane derivatives with good ee values.
The corresponding keto–alcohol compounds were then bioreduced by yeasts. The biotransformation
set up with Rhodo Torula rubra allowed (R)- keto– alcohols and (S, S)-diols to be obtained with up to 99% ee and up to 99% de in favor of the anti enantiomers.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Gandolfi, G. Facchetti, M. Christodoulou, M. Fusè, F. Meneghetti, I.S. Rimoldi
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