Data di Pubblicazione:
2015
Citazione:
Recent Advances in Lipase-Mediated Preparation of Pharmaceuticals and Their Intermediates / A.C. Lustosa de Melo Carvalho, T. de Sousa Fonseca, M.C. de Mattos, M. Ferreira de Oliveira, T.L. Gomes de Lemos, F. Molinari, D. Romano, I. Serra. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 16:12(2015 Dec), pp. 29682-29716. [10.3390/ijms161226191]
Abstract:
Biocatalysis offers an alternative approach to conventional chemical processes for the production of single-isomer chiral drugs. Lipases are one of the most used enzymes in the synthesis of enantiomerically pure intermediates. The use of this type of enzyme is mainly due to the characteristics of their regio-, chemo- and enantioselectivity in the resolution process of racemates, without the use of cofactors. Moreover, this class of enzymes has generally excellent stability in the presence of organic solvents, facilitating the solubility of the organic substrate to be modified. Further improvements and new applications have been achieved in the syntheses of biologically active compounds catalyzed by lipases. This review critically reports and discusses examples from recent literature (2007 to mid-2015), concerning the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and their intermediates in which the key step involves the action of a lipase.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
biocatalysis; enantioselectivity; kinetic resolution; lipases; pharmaceuticals
Elenco autori:
A.C. Lustosa de Melo Carvalho, T. de Sousa Fonseca, M.C. de Mattos, M. Ferreira de Oliveira, T.L. Gomes de Lemos, F. Molinari, D. Romano, I. Serra
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