Indoles rather than triazoles from the ruthenium porphyrin-catalyzed reaction of alkynes with aryl azides
Articolo
Data di Pubblicazione:
2014
Citazione:
Indoles rather than triazoles from the ruthenium porphyrin-catalyzed reaction of alkynes with aryl azides / P. Zardi, A. Savoldelli, D.M. Carminati, A. Caselli, F. Ragaini, E. Gallo. - In: ACS CATALYSIS. - ISSN 2155-5435. - 4:11(2014 Nov 07), pp. 3820-3823.
Abstract:
An unprecedented reactivity of aryl azides toward alkynes is presented herein. The reaction performed well in the presence of 2 mol % of ruthenium porphyrin catalysts and afforded substituted indoles instead of triazoles. The procedure is particularly appealing for the synthesis of C3-functionalized indoles which bear EWG on the fragment coming from the azide. The method allowed the synthesis of 15 derivatives with yields up to 95%, high regioselectivity, and without requiring the time-consuming prefunctionalization of reagents and the addition of oxidants and/or additives.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
alkyne; azide; indole; porphyrin; ruthenium; catalysis
Elenco autori:
P. Zardi, A. Savoldelli, D.M. Carminati, A. Caselli, F. Ragaini, E. Gallo
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