Data di Pubblicazione:
2009
Citazione:
Biocatalysis for the manufacture of pharma intermediates / F. Molinari. ((Intervento presentato al convegno Chimica Organica e Biotecnologie: Sfide e Opportunità tenutosi a Forte dei Marmi nel 2009.
Abstract:
The major goal of our research is the development of synthetically useful selective biotransformations using microbial enzymes by combining natural and non-natural conditions. Biotransformations to be used in pharmaceutical manufacturing has been studied.
Examples from our work will be presented with regards to these strategies, including different applications:
➢ Selective modification (deacylation and demannosilation) of lipoglycopeptide antibiotics by using hydrolases from actinomycetes. Case study: modification of ramoplanin
➢ Chemo- and enantioselective oxidations for the production of optically pure intermediates to be used for the synthesis of different drugs. Case study: chemoenzymatic synthesis of Captopril®
Different techniques have been exploited for improving the selectivity and/or productivity of the bioprocesses: reaction engineering, biocatalyst manipulation and reactor engineering.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
F. Molinari
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