Resolution of (R,S)-2-phenylpropanoic acid by enantioselective esterification with dry microbial cells in organic solvent
Articolo
Data di Pubblicazione:
2001
Citazione:
Resolution of (R,S)-2-phenylpropanoic acid by enantioselective esterification with dry microbial cells in organic solvent / R. Gandolfi, C. Zanchi, R. Gualandris, F. Molinari. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 12:5(2001), pp. 501-504. [10.1016/S0957-4166(01)00033-7]
Abstract:
The microbial direct esterification of racemic 2-phenyl-1-propanoic acid with ethanol by lyophilized mycelium of Aspergillus oryzae MIM and Rhizopus oryzae CBS 112.07 in organic solvents has been investigated. Dry cells of Rhizopus oryzae CBS 112.07 gave the (R)-ethyl ester with high enantiomeric excess (>97%) when the biotransformation was carried out in heptane or pentadecane. Dry mycelium of Aspergillus oryzae MIM furnished the ethyl ester of (S)-(+)-2-phenylpropanoic acid with 90% enantiomeric excess when used in toluene in a temperature range of 20-40°C.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Gandolfi, C. Zanchi, R. Gualandris, F. Molinari
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