Data di Pubblicazione:
2023
Citazione:
Antiviral, virucidal and antioxidant properties of Artemisia annua against SARS-CoV-2 / M. Baggieri, S. Gioacchini, G. Borgonovo, G. Catinella, A. Marchi, P. Picone, S. Vasto, R. Fioravanti, P. Bucci, M. Kojouri, R. Giuseppetti, E. D'Ugo, F. Ubaldi, S. Dallavalle, D. Nuzzo, A. Pinto, F. Magurano. - In: BIOMEDICINE & PHARMACOTHERAPY. - ISSN 1950-6007. - 168:(2023), pp. 115682.1-115682.12. [10.1016/j.biopha.2023.115682]
Abstract:
Natural products are a rich source o bioactive molecules that have potential pharmacotherapeutic applications.
In this study, we ocused on Artemisia annua (A. annua) and its enriched extracts which were biologically
evaluated in vitro as virucidal, antiviral, and antioxidant agents, with a potential application against the COVID-
19 inection. The crude extract showed virucidal, antiviral and antioxidant eects in concentrations that did not
aect cell viability. Scopoletin, arteannuin B and artemisinic acid (single ractions isolated rom A. annua)
exerted a considerable virucidal and antiviral eect in vitro starting rom a concentration o 50 μg/mL. Data rom
Surace Plasmon Resonance (SPR) showed that the inhibition o the viral inection was due to the interaction o
these compounds with the 3CLpro and Spike proteins o SARS-CoV-2, suggesting that the main interaction o
compounds may interere with the viral pathways during the insertion and the replication process. The present
study suggests that natural extract o A. annua and its components could have a key role as antioxidants and
antiviral agents and support the ght against SARS-CoV-2 variants and other possible emerging Coronaviruses.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
COVID-19, SARS-CoV2, Antiviral, Artemisia annua, Antioxidant activity, Artemisinic acid;
Elenco autori:
M. Baggieri, S. Gioacchini, G. Borgonovo, G. Catinella, A. Marchi, P. Picone, S. Vasto, R. Fioravanti, P. Bucci, M. Kojouri, R. Giuseppetti, E. D'Ugo, F. Ubaldi, S. Dallavalle, D. Nuzzo, A. Pinto, F. Magurano
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