Unraveling the parahormetic mechanism underlying the health-protecting effects of grapeseed procyanidins
Articolo
Data di Pubblicazione:
2024
Citazione:
Unraveling the parahormetic mechanism underlying the health-protecting effects of grapeseed procyanidins / G. Baron, A. Altomare, L. Della Vedova, F. Gado, O. Quagliano, S. Casati, N. Tosi, L. Bresciani, D. Del Rio, G. Roda, A. D'Amato, C. Lammi, A. Macorano, S. Vittorio, G. Vistoli, L. Fumagalli, M. Carini, A. Leone, M. Marino, C. Del Bo’, G. Miotto, F. Ursini, P. Morazzoni, G. Aldini. - In: REDOX BIOLOGY. - ISSN 2213-2317. - 69:(2024 Feb), pp. 102981.1-102981.14. [10.1016/j.redox.2023.102981]
Abstract:
Proanthocyanidins (PACs), the predominant constituents within Grape Seed Extract (GSE), are intricate compounds composed of interconnected flavan-3-ol units. Renowned for their health-affirming properties, PACs offer a shield against a spectrum of inflammation associated diseases, such as diabetes, obesity, degenerations and possibly cancer. While monomeric and dimeric PACs undergo some absorption within the gastrointestinal tract, their larger oligomeric and polymeric counterparts are not bioavailable. However, higher molecular weight PACs engage with the colonic microbiota, fostering the production of bioavailable metabolites that undergo metabolic processes, culminating in the emergence of bioactive agents capable of modulating physiological processes. Within this investigation, a GSE enriched with polymeric PACs was employed to explore in detail their impact. Through comprehensive analysis, the present study unequivocally verified the gastrointestinal-mediated transformation of medium to high molecular weight polymeric PACs, thereby establishing the bioaccessibility of a principal catabolite termed 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (VL). Notably, our findings, encompassing cell biology, chemistry and proteomics, converge to the proposal of the notion of the capacity of VL to activate, upon oxidation to the corresponding quinone, the nuclear factor E2-related factor 2 (Nrf2) pathway-an intricate process that incites cellular defenses and mitigates stress-induced responses, such as a challenge brought by TNFα. This mechanistic paradigm seamlessly aligns with the concept of para-hormesis, ultimately orchestrating the resilience to stress and the preservation of cellular redox equilibrium and homeostasis as benchmarks of health.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
(Poly)Phenols; 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone; Anti-inflammatory and antioxidant activities; Keap1; Metabolism; Microbiota; NFκB; Nrf2; Proanthocyanidins;
Elenco autori:
G. Baron, A. Altomare, L. Della Vedova, F. Gado, O. Quagliano, S. Casati, N. Tosi, L. Bresciani, D. Del Rio, G. Roda, A. D'Amato, C. Lammi, A. Macorano, S. Vittorio, G. Vistoli, L. Fumagalli, M. Carini, A. Leone, M. Marino, C. Del Bo’, G. Miotto, F. Ursini, P. Morazzoni, G. Aldini
Link alla scheda completa: