Data di Pubblicazione:
2023
Citazione:
Salivary proteomic profile of young healthy subjects / P. Dongiovanni, M. Meroni, G. Aiello, A. D'Amato, N. Cenzato, S. Casati, G. Damiani, C. Fenoglio, D. Galimberti, E. Grossi, D. Prati, G. Lamorte, C. Bianco, L. Valenti, A. Soggiu, S. Zapperi, C.A.M. La Porta, M. Del Fabbro, G.M. Tartaglia. - In: FRONTIERS IN MOLECULAR BIOSCIENCES. - ISSN 2296-889X. - 10:(2023), pp. 1327233.1-1327233.7. [10.3389/fmolb.2023.1327233]
Abstract:
Background: The incidence of noncommunicable diseases (NCDs) has been rapidly ramped up worldwide. Hence, there is an urgent need to non-invasively detect NCDs possibly by exploiting saliva as a 'liquid biopsy' to identify biomarkers of the health status. Since, the absence of standardized procedures of collection/analysis and the lack of normal ranges makes the use of saliva still tricky, our purpose was to outline a salivary proteomic profile which features healthy individuals. Methods: We collected saliva samples from 19 young blood donors as reference population and the proteomic profile was investigated through mass-spectrometry. Results: We identified 1,004 proteins of whose 243 proteins were shared by all subjects. By applying a data clustering approach, we found a set of six most representative proteins across all subjects including Coronin-1A, F-actin-capping protein subunit alpha, Immunoglobulin J chain, Prosaposin, 78 kDa glucose-regulated protein and Heat shock 70 kDa protein 1A and 1B. Conclusion: All of these proteins are involved in immune system activation, cellular stress responses, proliferation, and invasion thus suggesting their use as biomarkers in patients with NCDs.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
biomarker; healthy subjects; liquid biopsy; proteomic analysis; saliva
Elenco autori:
P. Dongiovanni, M. Meroni, G. Aiello, A. D'Amato, N. Cenzato, S. Casati, G. Damiani, C. Fenoglio, D. Galimberti, E. Grossi, D. Prati, G. Lamorte, C. Bianco, L. Valenti, A. Soggiu, S. Zapperi, C.A.M. La Porta, M. Del Fabbro, G.M. Tartaglia
Link alla scheda completa: