Data di Pubblicazione:
2007
Citazione:
Resolution of (R,S)-flurbiprofen catalysed by dry mycelia in organic solvent / P. Spizzo, A. Basso, C. Ebert, L. Gardossi, V. Ferrario, D. Romano, F.E. Molinari. - In: TETRAHEDRON. - ISSN 0040-4020. - 63:45(2007), pp. 11005-11010.
Abstract:
Mycelia of Aspergillus oryzae display high enantioselectivity towards (R)-flurbiprofen and can be efficiently used in pure organic solvent for the resolution of (R,S)-flurbiprofen through esterification. The use of the lyophilized mycelia facilitates the separation process so that in one step the two enantiomers of flurbiprofen, which are both valuable for pharmaceutical applications, can be easily separated. The biotransformation can be carried out in different apolar solvents using different primary alcohols as nucleophiles under very mild conditions.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P. Spizzo, A. Basso, C. Ebert, L. Gardossi, V. Ferrario, D. Romano, F.E. Molinari
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