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  1. Projects

Towards multi-stage drugs to fight poverty related and neglected parasitic diseases: synthetic and natural compounds directed against Leishmania, Plasmodium and Schistosoma life stages and assessment of their mechanisms of action.

Project
  • Overview
  • Publications

Overview

Departments involved

Dipartimento di Scienze Farmacologiche e Biomolecolari Rodolfo Paoletti   Principale  

Type

PRIN2015 - PRIN bando 2015

Funder

MINISTERO DELL'ISTRUZIONE E DEL MERITO
External Organization Funding Organization

Date/time interval

February 5, 2017 - February 4, 2020

Project duration

36 months

Publications

Outputs (8)

Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities 
BIOMOLECULES
MDPI
2023
Academic Article
Open Access
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Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds 
ACS MEDICINAL CHEMISTRY LETTERS
AMERICAN CHEMICAL SOCIETY (ACS)
2021
Academic Article
Open Access
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Antiplasmodial activity of triterpenes isolated from the methanolic leaf extract of Combretum racemosum P. Beauv 
JOURNAL OF ETHNOPHARMACOLOGY
ELSEVIER
2020
Academic Article
Reserved Access
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In vitro multistage malaria transmission blocking activity of selected malaria box compounds 
DRUG DESIGN, DEVELOPMENT AND THERAPY
DOVE MEDICAL PRESS
2020
Academic Article
Open Access
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4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania 
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ELSEVIER
2019
Academic Article
Reserved Access
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Identification of a potent and selective gametocytocidal antimalarial agent from the stem barks of Lophira lanceolata 
BIOORGANIC CHEMISTRY
ELSEVIER : ACADEMIC PRESS
2019
Academic Article
Reserved Access
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Interplay between Plasmodium falciparum haemozoin and L-arginine : implication for nitric oxide production 
MALARIA JOURNAL
BIOMED CENTRAL
2018
Academic Article
Open Access
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Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Mice 
ACS MEDICINAL CHEMISTRY LETTERS
ACS PUBLICATIONS
2018
Academic Article
Reserved Access
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