4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania
Articolo
Data di Pubblicazione:
2019
Citazione:
4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania / J.I. Manzano, J. Konstantinovic, D. Scaccabarozzi, A. Perea, A. Pavic, L. Cavicchini, N. Basilico, F. Gamarro, B.A. Solaja. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 180(2019 Oct 15), pp. 28-40. [10.1016/j.ejmech.2019.07.010]
Abstract:
Among neglected tropical diseases, leishmaniasis is one of the most relevant with an estimated 30,000 deaths annually. Existing therapies have serious drawbacks in safety, drug resistance, field-adapted application and cost; therefore, new safer and shorter treatments are needed for this disease. Here we report on the synthesis of novel 4-amino-7-chloroquinoline-based compounds with leishmanicidal activity, together with deeper insight into the mechanism of action of our previously published hit compound 1. New derivatives showed comparable activity to 1 against both promastigote and intracellular amastigote forms of Leishmania infantum, with IC50 < 1 μM. Furthermore, we have determined that compound 1 induced a decrease of intracellular ATP levels, as well as a mitochondrial depolarization, together with an alteration of plasma membrane permeability and a significant ROS production. The inhibition of the energy metabolism of Leishmania plays an important role in the leishmanicidal mechanism of this compound. In all, these results support the consideration of compound 1 for the future development of new leishmanicidal drugs.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
4-Aminoquinoline-based compounds; Drug combination; In vitro activity; Leishmania; Mechanism of action
Elenco autori:
J.I. Manzano, J. Konstantinovic, D. Scaccabarozzi, A. Perea, A. Pavic, L. Cavicchini, N. Basilico, F. Gamarro, B.A. Solaja
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