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  1. Third Mission

Joint Doctorate in Molecular Animal Nutrition (MANNA)

Project
The European “Joint Doctorate in Molecular Animal Nutrition” – MANNA – includes 6 universities, 9 private companies and 3 public research institutes from 8 European countries. The goal is to:
1) develop an Elite European School to train early stage researchers (ESR) in OMIC technologies applied to animal nutrition and in essential scientific, entrepreneurial and management skills;
2) evaluate the influence of innovative feed additives on animal production;
3) deliver double doctoral (PhD) degrees in a multidisciplinary and multi-sectoral network to develop a generation of internationally equipped scientists for the global workplace.
The objectives will be achieved by co-supervising each of 11 ESRs with two Beneficiary Universities and a nonacademic participant. They will work on integrated innovative research projects, designed to investigate the effects of anti-oxidants, microRNA, exosomes, methionine, lipids and plant derived anti-inflammatories in livestock diets on growth, intestinal health and systemic metabolism which will be assessed by integrating transcriptomic, microbiomic, proteomic and metabolomic approaches in both in vivo and in vitro models. The results will go into informatic
platforms to build analytic systems based on IBM-Watson cognitive computing. Secondments will enhance the research programmes of all ESR being based in industry and non-academic research institutes, whose field of activity include animal nutrition, veterinary diagnostic and clinical research, bioinformatics and professional communication in the agro-food sector. All will contribute to training by including ESR in their working team, and providing lectures and training sessions in Summer Schools and workshops which will reinforce the graduate programmes of each
University. The joint governance structure of MANNA will manage the recruitment, supervision and assessment processes across the network and will become embedded in the future post graduate education of each University
  • Overview
  • Publications

Overview

Contributors (2)

CECILIANI FABRIZIO   Scientific Manager  
SAVOINI GIOVANNI   Scientific Manager  

Departments involved

Dipartimento di Medicina Veterinaria e Scienze Animali   Principale  

Type

H20MCITNIF - Horizon 2020_Marie Skłodowska-Curie actions-Innovative Training Network (ITN)/Individual Fellowships (IF)

Funder

EUROPEAN COMMISSION
External Organization Funding Organization

Date/time interval

June 1, 2018 - May 31, 2022

Project duration

48 months

Publications

Outputs (29)

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  • Abstract
  • Academic Article
Assessment of the fecal microbiota from sow to piglet and the impact of different ratios of dietary polyunsaturated fatty acids 
INTERNATIONAL SOCIETY FOR ANIMAL GENETICS
2021
Abstract
Comparative proteome profiling in exosomes derived from porcine colostrum versus mature milk 
JOURNAL OF EXTRACELLULAR VESICLES
INTERNATIONAL SOCIETY FOR EXTRACELLULAR VESICLES
2021
Abstract
Muscle proteomics of preweaning piglets from sows fed diets with extreme n6/n3 fatti acid ratios 
INTERNATIONAL SOCIETY FOR ANIMAL GENETICS
2021
Abstract
Tandem mass tag-based proteomics for studying the effects of low dietary ω6:ω3 fatty acid ratio during gestation and lactation on plasma protein profiles in pigs 
BRITISH SOCIETY FOR PROTEOME RESEARCH
2021
Abstract
The ratio of n6/n3 fatty acids in the maternal diet affects the composition of microRNA contained in exosomes from blood plasma of piglets 
JOURNAL OF EXTRACELLULAR VESICLES
INTERNATIONAL SOCIETY FOR EXTRACELLULAR VESICLES
2021
Abstract
Porcine milk small extracellular vesicles modulate peripheral blood mononuclear cell proteome in vitro 
SCIENTIFIC REPORTS
SPRINGER NATURE LONDON
2025
Academic Article
Open Access
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Untargeted lipidomics reveals unique lipid signatures of extracellular vesicles from porcine colostrum and milk 
PLOS ONE
PUBLIC LIBRARY OF SCIENCE PLOS
2025
Academic Article
Open Access
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Citrus pectin modulates chicken peripheral blood mononuclear cell proteome in vitro 
POULTRY SCIENCE
ELSEVIER
2024
Academic Article
Open Access
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Conjugated linoleic acid (CLA) modulates bovine peripheral blood mononuclear cells (PBMC) proteome in vitro 
JOURNAL OF PROTEOMICS
ELSEVIER
2024
Academic Article
Open Access
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The skimmed milk proteome of dairy cows is affected by the stage of lactation and by supplementation with polyunsaturated fatty acids 
SCIENTIFIC REPORTS
SPRINGER NATURE
2024
Academic Article
Open Access
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Comprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes 
SCIENTIFIC REPORTS
SPRINGER NATURE PUBLISHING GROUP
2023
Academic Article
Open Access
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Exon–intron split analysis reveals posttranscriptional regulatory signals induced by high and low n-6/n-3 polyunsaturated fatty acid ratio diets in piglets 
JOURNAL OF ANIMAL SCIENCE
OXFORD ACADEMIC : AMERICAN SOCIETY OF ANIMAL SCIENCE
2023
Academic Article
Open Access
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Porcine milk exosomes modulate the immune functions of CD14+ monocytes in vitro 
SCIENTIFIC REPORTS
SPRINGER
2023
Academic Article
Open Access
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Review: Effect of essential fatty acids and conjugated linoleic acid on the adaptive physiology of dairy cows during the transition period 
ANIMAL
ELSEVIER
2023
Academic Article
Open Access
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Abundance of plasma proteins in response to divergent ratios of dietary ω6:ω3 fatty acids in gestating and lactating sows using a quantitative proteomics approach 
JOURNAL OF PROTEOMICS
ELSEVIER
2022
Academic Article
Open Access
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Effects of different ratios of omega-6:omega-3 fatty acids in the diet of sows on the proteome of milk-derived extracellular vesicles 
JOURNAL OF PROTEOMICS
ELSEVIER
2022
Academic Article
Reserved Access
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Immunomodulatory effects of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) on porcine monocytes (CD14 +) immune response in vitro 
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
ELSEVIER B.V.
2022
Academic Article
Partially Open Access
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Investigating circulating miRNA in transition dairy cows: What miRNAomics tells about metabolic adaptation 
FRONTIERS IN GENETICS
FRONTIERS MEDIA
2022
Academic Article
Open Access
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Longitudinal liver proteome profiling in dairy cows during the transition from gestation to lactation : Investigating metabolic adaptations and their interactions with fatty acids supplementation via repeated measurements ANOVA-simultaneous component analysis 
JOURNAL OF PROTEOMICS
ELSEVIER
2022
Academic Article
Partially Open Access
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Low n-6/n-3 gestation and lactation diets influence early performance, muscle and adipose polyunsaturated fatty acid content and deposition, and relative abundance of proteins in suckling piglets 
MOLECULES
MDPI
2022
Academic Article
Open Access
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Plasma proteomics reveals crosstalk between lipid metabolism and immunity in dairy cows receiving essential fatty acids and conjugated linoleic acid 
SCIENTIFIC REPORTS
NATURE PUBLISHING GROUP
2022
Academic Article
Open Access
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Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed part I : Serum proteomes 
JOURNAL OF PROTEOMICS
ELSEVIER
2022
Academic Article
Partially Open Access
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Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed part II : Ileum proteomes 
JOURNAL OF PROTEOMICS
ELSEVIER
2022
Academic Article
Open Access
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Role of Short Chain Fatty Acids to Counteract Inflammatory Stress and Mucus Production in Human Intestinal HT29-MTX-E12 Cells 
FOODS
MDPI
2022
Academic Article
Open Access
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Role of omega-3 polyunsaturated fatty acids, citrus pectin, and milk-derived exosomes on intestinal barrier integrity and immunity in animals 
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
BIOMED CENTRAL
2022
Academic Article
Open Access
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Comparative proteome profiling in exosomes derived from porcine colostrum versus mature milk reveals distinct functional proteomes 
JOURNAL OF PROTEOMICS
ELSEVIER
2021
Academic Article
Reserved Access
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Effects of Low ω6:ω3 Ratio in Sow Diet and Seaweed Supplement in Piglet Diet on Performance, Colostrum and Milk Fatty Acid Profiles, and Oxidative Status 
ANIMALS
MDPI
2020
Academic Article
Open Access
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In vitro effects of conjugated linoleic acid (CLA) on inflammatory functions of bovine monocytes 
JOURNAL OF DAIRY SCIENCE
ELSEVIER
2020
Academic Article
Partially Open Access
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Omega-3 Polyunsaturated Fatty Acids Counteract Inflammatory and Oxidative Damage of Non-Transformed Porcine Enterocytes 
ANIMALS
MDPI
2020
Academic Article
Open Access
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