Alternative translation initiation as a novel strategy to block toxicity of the mutant Androgen Receptor in SBMA

Project

Overview

Contributors

POLETTI ANGELO   Scientific Manager  

Departments involved

Type

FON_NAZ - Bandi Altre Fondazioni

Funder

FONDAZIONE TELETHON ETS
External Organization Funding Organization

Date/time interval

December 1, 2019 - November 30, 2022

Project duration

36 months

Research Areas

Concepts


Settore BIO/13 - Biologia Applicata

Publications

Outputs (15)

The alternative androgen receptor isoform a mitigates toxicity of polyglutamine-elongated mutant androgen receptor in spinal and bulbar muscular atrophy 
JOURNAL OF ADVANCED RESEARCH
ELSEVIER
2026
Academic Article
Open Access
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VCP modulation ameliorates pathological features in C9orf72 models 
CELL DEATH & DISEASE
NATURE GROUP-SPRINGER
2026
Academic Article
Open Access
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Impairment of lysosomal quality control in Huntington disease 
CELL DEATH & DISEASE
SPRINGER NATURE
2025
Academic Article
Open Access
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Targeting androgen receptor stability and degradation: approaches for developing a therapy for spinal and bulbar muscular atrophy 
CELL COMMUNICATION AND SIGNALING
BIOMED CENTRAL
2025
Academic Article
Open Access
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Altered molecular and cellular mechanisms in KIF5A-associated neurodegenerative or neurodevelopmental disorders 
CELL DEATH & DISEASE
SPRINGER NATURE PUBLISHING GROUP
2024
Academic Article
Open Access
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Lysosome quality control in health and neurodegenerative diseases 
CELLULAR AND MOLECULAR BIOLOGY LETTERS
BIOMED CENTRAL
2024
Academic Article
Open Access
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The chaperone-assisted selective autophagy complex dynamics and dysfunctions 
AUTOPHAGY
2023
Academic Article
Open Access
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HSPB8 counteracts tumor activity of BRAF- and NRAS-mutant melanoma cells by modulation of RAS-prenylation and autophagy 
CELL DEATH & DISEASE
SPRINGER NATURE
2022
Academic Article
Open Access
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Insights on human small heat shock proteins and their alterations in diseases 
FRONTIERS IN MOLECULAR BIOSCIENCES
FRONTIERS MEDIA
2022
Academic Article
Open Access
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Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy 
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
MDPI
2022
Academic Article
Open Access
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C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation 
EMBO JOURNAL
EMBO PRESS
2021
Academic Article
Open Access
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Retinoic Acid Downregulates HSPB8 Gene Expression in Human Breast Cancer Cells MCF-7 
FRONTIERS IN ONCOLOGY
FRONTIERS
2021
Academic Article
Open Access
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The Role of HSPB8, a Component of the Chaperone-Assisted Selective Autophagy Machinery, in Cancer 
CELLS
MDPI
2021
Academic Article
Open Access
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A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases 
FRONTIERS IN AGING NEUROSCIENCE
FRONTIERS MEDIA
2020
Academic Article
Open Access
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BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes 
SCIENTIFIC REPORTS
NATURE PUBLISHING GROUP
2020
Academic Article
Open Access
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