From basic knowledge on the dynamics of b2-m self aggregation to the discovery of new inhibitors of amyloidogenesis

The UNIMI unit will focus on: (i) different structural and morphological issues involving monomeric and aggregated ß2-m, aiming to determine the amyloidogenic determinants of monomeric ß2-m and the conformational changes occurring during aggregation; (ii) the structural analysis of complexes of ß2-m and ligands of pharmacological interest; (iii) the study of the structure of ß2-m amyloids alone and in complex with a number of physiological and anti-aggregation ligands.