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  1. Third Mission

Synapses: from molecules to higher brain function and diseases

Project

SyMBaD aims to move forward our knowledge on synapse structure and function in the normal and pathological brain. Brain diseases represent a considerable social and economic burden in Europe. Emerging evidence indicates that synaptic dysfunction is associated with a majority of neurological and psychiatric disorders. Novel therapeutical approaches relie on a better knowledge of the synapse and its pathologies. The network comprises 23 teams from 6 academic centres (Bordeaux, Alicante, Milan, Geneva, Gottingen, Bristol) representing an important fraction of the leading European researchers in the field. Synergies and complementarities between the research teams exist and should develop with the activities of the SyMBaD network. The participants are already well integrated in European scientific collaborative networks, and have an outstanding track-record of training young researchers. Industrial partners (6) will take part as full partners in training by an obligatory placement from 6 to 12 months of 16 ESR among the 26 recruited. The other ESR will be fully integrated into collaborative projects between academic teams. The private sector comprises companies involved in the development of new therapeutical strategies to combat brain diseases (GSK, Neurosearch, Xygen, and Noscira) and companies involved in technical development to be used in synaptic research and beyond (Bioxtal, Amplitude Systems, Explora Nova). The SYMBAD network aims to: Teach a number of increasingly sophisticated techniques required in neuroscience and to advance towards novel therapies. Focus on technological innovation and on interweaving of multilevel approaches. Facilitate future constructive dialogue between academia and industry in the field by involving SMEs in the training of PhD students through collaborative research projects.

  • Overview
  • Research Areas
  • Publications

Overview

Contributors

DILUCA MONICA MARIA GRAZIA   Scientific Manager  

Type

7PQ_MC - 7 Programma Quadro_Marie Curie ITN_IEF_IOF_IIF_IAPP

Funder

EUROPEAN COMMISSION
External Organization Funding Organization

Date/time interval

December 1, 2009 - November 30, 2013

Project duration

48 months

Research Areas

Concepts (3)


72.19.09 - Ricerca e sviluppo sperimentale nel campo delle altre scienze naturali e dell'ingegneria

LS5_11 - Neurological disorders (e.g. Alzheimer’s disease, Huntington’s disease, Parkinson’s disease) - (2013)

LS5_3 - Neurochemistry and neuropharmacology - (2013)

Keywords (2)

PARKINSON'S DISEASE
SYNAPTIC DYSFUNCTION
No Results Found

Publications

Outputs (2)

Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus 
ELIFE
2016
Academic Article
Open Access
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Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex 
NATURE COMMUNICATIONS
NATURE PUBLISHING GROUP
2015
Academic Article
Open Access
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