MONTINI GIOVANNI

Personal Details
First name / Surname: Giovanni MONTINI
Address: Via Ponte della Cagna, 104, 35142, Padova, Italia
Telephone: +39 02 550302336 work - Mobile: +39 3472509709
E-mail giovanni.montini@unimi.it
Nationality Italian
Date of birth 05/02/1958


Occupational Field: Paediatric Nephrologist with special interest in the following areas of medicine and research: Urinary tract infections, paediatric renal transplantation, chronic and acute kidney failure, CAKUT, nephrotic syndrome, renal involvement in mitochondrial diseases.

Work Experience

July 2015 to present
Director of the Paediatric Nephrology and Dialysis Unit
Dipartimento della Donna, del Bambino e del Neonato
U.O.C. Nefrologia e Dialisi Pediatrica,
Fondazione IRCCS Cà Granda – Ospedale Maggiore Policlinico
Via Commenda 9, 20122, Milano

1 January 2020 to present
Full Professor of Paediatrics
Department of Clinical Sciences and Community Health
Università delgi Studi di Milano
Via Festa del Perdono, 7 - 20122 - Milano.

1 July 2015 to 31 December 2019
Associate Professor of Paediatrics
Department of Clinical Sciences and Community Health
Università delgi Studi di Milano
Via Festa del Perdono, 7 - 20122 - Milano.

April 2009 to June 2015
Consultant in Paediatric Nephrology
Chief of the Paediatric Nephrology and Dialysis Unit
Dipartimento ad Attività Integrata Salute della Donna, del Bambino e dell’Adolescente
U.O. di Pediatria, Azienda Ospedaliero-Universitaria Sant’Orsola-Malpighi
Via Massarenti 11, 40138, Bologna.
Recruited in April 2009 to set up the Paediatric Nephrology Unit in Bologna which
currently offers services including day hospital and outpatient clinics for the various
paediatric nephrology subspecialties and dialysis. In 2012, the paediatric renal transplant programme was initiated. The Unit is now a reference centre for paediatric nephrology in the Emilia-Romagna region. A wide-ranging clinical research programme has also been set up including the development and management of national and international protocols in the field of paediatric nephrology.

September 2008 to March 2009
Honorary Consultant in Paediatric Nephrology
Department of Paediatric Nephrology,
Great Ormond Street Hospital for Sick Children,
Great Ormond Street, London, WC1N 3JH, England.
Clinical and research responsibilities concentrating mainly on congenital nephrotic
syndrome and the treatment of hypertension.

January 1989 to August 2008
Consultant in Paediatric Nephrology
1a Clinica Pediatrica - Azienda Ospedaliera di Padova, Via Giustiniani, 2, 35128, Padova.
Active participation in the development of the Paediatric Nephrology Department of
Padua Hospital over the 20 years in service there. Main areas of contribution include the
dialysis and transplant programme (management of around 400 paediatric transplant recipients), with special duties regarding renal replacement therapy. A great contribution in terms of organisational, research (PI for national multicenter trials) and didactic activities.

October 1987 to December 1988
Registrar in Pediatric Nephrology
Department of Paediatric Nephrology,
Guy's Hospital, Great Maze Pond, London, SE1 9RT.
Period of training at one the most internationally renowned departments of Paediatric
Nephrology, directed by Prof. Cyril Chantler. During this period of clinical experience the
following areas were concentrated on: renal transplantation and chronic renal failure.
Research topics included methods of calculation of glomerular filtration rate and the use of recombinant human erythropoietin in the treatment of uremic anaemia.

From 1982 to 1986
Resident in Paediatrics specializing in nephrology and gastroenterology.
1a Clinica Pediatrica - Azienda Ospedaliera di Padova, Via Giustiniani, 2, 35128, Padova.


Education and Training
From 1988 to 1991
Postgraduate Medical School Programme, University of Padua.
Postgraduate Specialization in Nephrology

From 1982 to 1986
Postgraduate Medical School Programme, University of Padua.
Postgraduate Specialization in Paediatrics

From 1976 to 1982
Degree in Medicine and Surgery
School of Medicine, University of Padua.

Periods of Study Abroad
September 2008 to March 2009
Honorary Consultant, Department of Paediatric Nephrology at Great Ormond Street Hospital for Sick Children, London.
November 1995
Visiting paediatric nephrologist at the Department of Paediatric Nephrology, Charlottesville Hospital, Virginia, USA:
March 1991
Period of study regarding the use of photophoresis in nephrological and rheumatic diseases at The Vienna General Hospital (Allgemeines Krankenhaus), Univeristy of Vienna, Austria.
December 1990
Visiting Research Fellow at Guy’s Hospital, London.
October 1987 to December 1988
Resident Paediatrician at the Department of Paediatric Nephrology at Guy’s Hospital, London.

Personal skills and competences

Mother tongue: Italian

Other languages: English, French, Spanish

Computer skills and competences
Good command of Microsoft Office tools (Word, Excel, PowerPoint), Internet Explorer, Outlook.

Scientific Activities

He is the author of 110 publications that principally relate to kidney diseases in children; all publications are in international peer reviewed journals. Publications were cited 2910 times, with an average of citations for each equal to 27.71 and an index "h" equal to 31 (as reported by Web of Science).

Principal National and International Research Projects:
Lead Investigator of the following research projects funded by grants obtained through national competitive grant programmes:

• A phase 2 open-label study to evaluate the efficacy of allogeneic human cord blood-derived mesenchymal stromal cells in maintaining remission after immunosuppressive therapy withdrawal in pediatric patients with steroid-dependent nephrotic syndrome. AIFA-2016-02364896 - Italian Medicines Agency Research Grant (2018-present)
• Antibiotic prophylaxis in infants with congenital abnormalities of kidney and urinary tract: the impact on the developmental trajectory of gut microbiome assembly, metabolic programming and the gut resistome profile. RF-2016-02363563 - Italian Ministry of Health Research Grant (2018-present)
• The PREDICT Trial (Antibiotic Prophylaxis and REnal Damage In Congenital abnormalities of the kidney and urinary Tract) (2013- present) RF-2010-2308451 - Italian Ministry of Health Research Grant CUP E35J12000230001
• Haemorrhagic Diarrhoea caused by shiga-like toxin-producing E.Coli Syndrome: epidemiology, virulence characteristics, risk factors in the Emilia Romagna Region. Emilia Romagna Region Research Grant CUP E35J11000400002 (2011-2013)
• The IRIS 1 Trial: Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial (1998- 2005)
Veneto Region Research Grant NCT00161330
• The IRIS 2 Trial: Evaluation of the Effectiveness of Antibiotic Prophylaxis in Children With a Previous Urinary Tract Infection (1998- 2005)
Veneto Region Research Grant NCT00156546

Principal Investigator of other research projects:

• An International Multicentre Registry Study on Autosomal Recessive Polycystic Kidney Diseases (ARPKD) - ARegPKD (2016 - present)
• A Phase 3b, Two-part, One Year Randomized, Double-blind, Palcebo-controlled Trial of the Safety, Pharmacokinetics, Tolerability, and Efficay of Tolvaptan followed by a Two Year Open-label Extension in Children and Adolescent Subjects with Autosomal Dominant Polycystic Kidney Disease (ADPKD): Otsuka Pharmaceutical Development and Commercialization Inc. (2016 - present)
• A 12-month, multicenter, open label, randomized, controlled study to evaluate the efficacy, tolerability and safety of early introduction of everolimus, reduced CNI, and early steroid elimination compared to standard CNI, mycophenolate mofetil and steroid regimen in paediatric renal transplant recipients with a 24-month additional safety follow-up: Novartis (2013 - present)
• The RESCUE Trial - Oral Steroids for reducing renal scarring in infants with febrile urinary tract infections at high risk for renal scar development: a randomized controlled trial. Italian Ministry of Health Research Grant (2012 - 2017)
• PROPINE study: Prospective Randomized study to Optimize Prednisone therapy for relapses of Idiopathic NEphrotic syndrome in children Idiopathic nephrotic syndrome in children - AIFA (2012-2017)
• A 6 week, randomized, multicenter, double-blind, double-dummy study to evaluate the dose response of valsartan on blood pressure reduction in children 1-5 years old with hypertension, with or without chronic kidney disease, followed by a 20 week open-label titration phase: Novartis (2012-2017)
• SNI-NET Trial: Steroid Treatment of Childhood Idiopathic Nephrotic Syndrome: epidemiology, therapeutic adequacy, medium and long term outcomes. A prospective observational cohort study (www.nefrokid.it) (2012-2017) Lead Investigator
• Long term outcome of patients with congenital solitary kidney” (2012-2017)
• Valsartan and Enalapril in Children with Hypertension Trial, Novartis - Investigator
• The CINCH Trial: A Dose ranging, safety and pharmacokinetics study of Candesartan Cilexetil in bypertensive paediatric subjects 1 to less than 6 years of age: A 4 week , multicenter, randomised, double blind study with a 1 year open label follow up period. (2006-2009)
• Lead Investigator and co-founder of the IRIS (Italian Renal Infection Study) study group (1998-2007)
• Investigator for the European study group for Blood Pressure Control and Progression of Chronic Renal Failure in Children (ESCAPE Trial) (1998-present)
• Lead Investigator of the EPO trial for the Italian Registry of Peritoneal Dialysis in children (1990 -1993)


Principal National and International Study Groups

• May 2013 to present, Board Member of the ESPN working group on CAKUT, UTI and bladder disorders.
• May 2013 to present, Coordinator of the Italian Society of Paediatric Nephrology study group on urinary tract infections in children.
• 2000 to 2005, Member of the Scientific Committee of Italkid: Italian Registry of chronic Kidney Disease in children.
• 1998 to present, Member of the ESCAPE Trial European study group: Blood pressure control and the progression of renal failure in children.
• Member of the Scientific Committee of the Italian Hemolytic-Uremic Syndrome surveillance programme
• 1998 to 2007, Coordinator of the IRIS study group: Italian Renal Infection Study Group.

Member of the following Scientific Societies:

Italian Society of Pediatric Nephrology, International Pediatric Nephrology Association, European Society of Pediatric Nephrology, Italian Society of Nephrology,Italian Society of Pediatrics, European Renal Association – European Dialysis and Transplantation Association.

Scientific Committees
• From 2017 to present, Council Member of the International Pediatric Nephrology Association (IPNA).
• November 2014 to 2016 - President of the Italian Society of Pediatric Nephrology
• October 2013 – October 2014, President Elect of the Italian Society of Pediatric Nephrology
• From May 2013 to present - Member of the Scientific Committee of the Charity Organization “Associazione per il Bambino Nefropatico” (ABN).
• From 2013 to present - Member of the Advisory Committee of EiP – Excellence in Pediatrics Institute
• From 2011 to present – Member of the Board of the European Society for Pediatric Nephrology
• From 2008 to present - President of the Scientific Committee of the Charity Organization “Il Sogno di Stefano” for children with kidney disease.
• From 2006 to 2008 – Member and Vice President of the board of the Italian Society of Pediatric Nephrology
• From 2000 to 2005, Board Member of Italkid: Italian Registry of chronic Kidney Disease in children.
• From 1992 to 1995 - Member of the board and Secretary of the Italian Society of Pediatric Nephrology
• From 1992 to 1994 - Member of the board of the Italian Society of Pediatric Nephrology

Didactic Activities
- A.Y. 2017-8, 2018-9, 2020-21 Lecturer: Specialization Course in Neonatal Intensive Care University of Milan
- A.Y. 2017-8, 2018-9, 2020-21 Lecturer: Professional Master Course in Pediatric Nephrology and Urology- University of Milan
- A.Y. 2016-7 Lecturer: Professional Master Course in Renal Pathology - University of Milan - A.A. 2016-7 Lecturer: Professional Master Course in Pediatric Urology - University of Florence
- From A.Y. 2017-8 to present: Lecturer: General and Specialist Pediatrics in English,The International Medical School, Faculty of Medicine and Surgery - University of Milan
- From A.Y. 2017-8 to present: Lecturer for the Pediatrics Module of the Degree Course in Orthoptics, University of Milan
- From A.Y. 2016-7 to present: Lecturer: School of Specialization in Urology, University of Milan
- From A.Y. 2015-6 to present: Lecturer for the Schools of Specialization in Nephrology, Pediatrics and Neurosurgery, University of Milan
- From A.Y. 2015-6 to present: Lecturer in General and Specialist Pediatrics, Degree Course in Medicine and Surgery Faculty of Medicine and Surgery - University of Milan - A.Y. 2015-6: Lecturer: Specialization Course in Urgenza-emergenza specialistica nell'età evolutiva - University of Milan
- From A.Y 2012-3 to June 2015: Adjunct Professor: School of Specialization in Nephrology, University of Bologna
- From A.Y 2011-2 to June 2015: Adjunct Professor: School of Specialization in Pediatrics, University of Bologna
- From A.Y 1990-1 to October 2008: Adjunct Professor: School of Specialization in Pediatrics (Pediatric Nephrology and Neonatal Intensive Care), University of Padua
- From A.Y 1991-2-3 to October 2008: Adjunct Professor: School of Specialization in Nephrology, University of Padua

Editorial Activities
• From January 2014 – member of the Editorial Board of the ‘Journal of Nephrology’
• From 2013 to present - member of the Editorial Board of ‘The Scientific World Journal’
• From September 2013 to present - member of the Editorial Board of ‘Case Reports in Pediatrics’
• From November 2012 to present – member of the Editorial Board of ‘Pediatric Nephrology’
• Referee for many international scientific journals including: Pediatric Nephrology, International Journal of Artificial Organs, Pediatric Transplantation, Pediatric Infectious Diseases, Kidney international, Pediatrics, Journal of Pediatrics, American Journal of Kidney Diseases.


- From 2019 - Scientific Director of the 'Biblioteca del Polo Centrale di Medicina e Chirurgia' for the academic period 2018/2021 (from 7.05.2019 until 30.9.2021)
- From 2018 - Member of the Joint Committee of the University of Milan and the Provincial Order of Physicians, Surgeons and Dentists for the Medical Board Certification examination.
- From 2017 - Member of the Milan Area B Ethics Committee
- Director of the Select Committee and Coordinator of the Sergio Bonelli Center for the prevention and cure of renal damage secondary to congenital malformations of the kidney and urinary tract: a center of national importance involving pediatric nephrologists, pediatric urologists and obstetricians in the premature diagnosis, treatment and prevention of renal damage in the fetus and child.
- A.Y. 2017/8 to A.Y. 2019/20 – President of the Collegio Didattico Interdipartimentale del Corso di Laurea Magistrale a Ciclo Unico in Medicina e Chirurgia (Polo Centrale), Dipartimento di Scienze Cliniche e di Comunità, University of Milan
- Coordinator of the 2nd Level Vocational Master Course in Pediatric Nephrology and Urology, University of Milan A.Y. 2017-8, A.Y. 2018-9, A.Y. 2020-21
- Since 2010, part of an international cooperation network project for pediatric nephrology set up in Nicaragua to help underprivileged children with kidney disease gain access to medical care, dialysis and transplantation. Project Director since 2018.