Data di Pubblicazione:
2019
Citazione:
Oncogenic virome benefits from the different vaginal microbiome-immune axes / G. Campisciano, T. Gheit, F. De Seta, C. Cason, N. Zanotta, S. Delbue, G. Ricci, P. Ferrante, M. Tommasino, M. Comar. - In: MICROORGANISMS. - ISSN 2076-2607. - 7:10(2019), pp. 414.1-414.14. [10.3390/microorganisms7100414]
Abstract:
The picture of dynamic interaction between oncogenic viruses and the vaginal bacteria-immune host milieu is incomplete. We evaluated the impact of Polyomaviridae, Papillomaviridae, and Herpesviridae oncoviruses on the vaginal Community State Types (CSTs) and host immune response in reproductive-age women. In our cohort, only Polyomaviridae and Papillomaviridae were detected and were associated with changes in the resident bacteria of CST I and IV (p < 0.05). Lactobacillus crispatus increased in CST I while Prevotella timonensis and Sneathia sanguinegens increased in CST IV. Conversely, CST II and III showed an alteration of the immune response, with the decrease of Eotaxin, MCP-1, IL-7, IL-9, and IL-15 (p < 0.05), leading to reduced antiviral efficacy. An efficient viral clearance was observed only in women from CST I, dominated by Lactobacillus crispatus. Our in vivo study begins to address the knowledge gap with respect to the role of vaginal bacteria and immune response in susceptibility to oncoviral infections.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bacteriome; Immune response; Vagitypes; Virome
Elenco autori:
G. Campisciano, T. Gheit, F. De Seta, C. Cason, N. Zanotta, S. Delbue, G. Ricci, P. Ferrante, M. Tommasino, M. Comar
Link alla scheda completa: