Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
Articolo
Data di Pubblicazione:
2009
Citazione:
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease / J..C. Lambert, S. Heath, G. Even, D. Campion, K. Sleegers, M. Hiltunen, O. Combarros, D. Zelenika, M..J. Bullido, B. Tavernier, L. Letenneur, K..B.C. Berr, F. Pasquier, N. Fiévet, P. Barberger Gateau, S. Engelborghs, P. De Deyn, I. Mateo, A. Franck, S. Helisalmi, E. Porcellini, O. Hanon, M..M. de Pancorbo, C. Lendon, C. Dufouil, C. Jaillard, T. Leveillard, V. Alvarez, P. Bosco, M. Mancuso, F. Panza, B. Nacmias, P. Bossù, P. Piccardi, G. Annoni, D. Seripa, D. Galimberti, D. Hannequin, F. Licastro, H. Soininen, K. Ritchie, H. Blanché, J..F. Dartigues, C. Tzourio, I. Gut, C. Van Broeckhoven, A. Alpérovitch, M. Lathrop, P. Amouyel, B. Arosio, E. Coto, M..D. Zompo, V. Deramecourt, J. Epelbaum, P. Forti, A. Brice, R. Ferri, E.A. Scarpini, G. Siciliano, V. Solfrizzi, S. Sorbi, G. Spalletta, G. Ravaglia, J. Sahel, F. Valdivieso, S. Vepsäläinen, A. Pilotto. - In: NATURE GENETICS. - ISSN 1061-4036. - 41:10(2009 Oct), pp. 1094-1100. [10.1038/ng.439]
Abstract:
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide association study of 2,032 individuals from France with Alzheimer's disease (cases) and 5,328 controls. Markers outside APOE with suggestive evidence of association (P < 10(-5)) were examined in collections from Belgium, Finland, Italy and Spain totaling 3,978 Alzheimer's disease cases and 3,297 controls. Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 x 10(-9) for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.14-1.29, P = 3.7 x 10(-9) for combined data). Previous biological studies support roles of CLU and CR1 in the clearance of beta amyloid (Abeta) peptide, the principal constituent of amyloid plaques, which are one of the major brain lesions of individuals with Alzheimer's disease.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
J.C. Lambert, S. Heath, G. Even, D. Campion, K. Sleegers, M. Hiltunen, O. Combarros, D. Zelenika, M.J. Bullido, B. Tavernier, L. Letenneur, K.B.C. Berr, F. Pasquier, N. Fiévet, P. Barberger Gateau, S. Engelborghs, P. De Deyn, I. Mateo, A. Franck, S. Helisalmi, E. Porcellini, O. Hanon, M.M. de Pancorbo, C. Lendon, C. Dufouil, C. Jaillard, T. Leveillard, V. Alvarez, P. Bosco, M. Mancuso, F. Panza, B. Nacmias, P. Bossù, P. Piccardi, G. Annoni, D. Seripa, D. Galimberti, D. Hannequin, F. Licastro, H. Soininen, K. Ritchie, H. Blanché, J.F. Dartigues, C. Tzourio, I. Gut, C. Van Broeckhoven, A. Alpérovitch, M. Lathrop, P. Amouyel, B. Arosio, E. Coto, M.D. Zompo, V. Deramecourt, J. Epelbaum, P. Forti, A. Brice, R. Ferri, E.A. Scarpini, G. Siciliano, V. Solfrizzi, S. Sorbi, G. Spalletta, G. Ravaglia, J. Sahel, F. Valdivieso, S. Vepsäläinen, A. Pilotto
Link alla scheda completa: