Molecular physiology of the insect K-activated amino acid transporter 1 (KAAT1) and cation-anion activated amino acid transporter/channel 1 (CAATCH1) in the light of the structure of the homologous protein LeuT
Articolo
Data di Pubblicazione:
2009
Citazione:
Molecular physiology of the insect K-activated amino acid transporter 1 (KAAT1) and cation-anion activated amino acid transporter/channel 1 (CAATCH1) in the light of the structure of the homologous protein LeuT / M. Castagna, E. Bossi, V.F. Sacchi. - In: INSECT MOLECULAR BIOLOGY. - ISSN 0962-1075. - 18:3(2009), pp. 265-279.
Abstract:
K-activated amino acid transporter 1 (KAAT1) and
cation-anion-activated amino acid transporter/channel
1 (CAATCH1) are amino acid cotransporters, belonging
to the Na/Cl-dependent neurotransmitter transporter
family (also called SLC6/NSS), that have been cloned
from
Manduca sexta
midgut. They have been thoroughly
studied by expression in
Xenopus laevis
oocytes, and
structure/function analyses have made it possible to
identify the structural determinants of their cation
and amino acid selectivity. About 40 mutants of these
proteins have been studied by measuring amino acid
uptake and current/voltage relationships. The results
obtained since the cloning of KAAT1 and CAATCH1
are here discussed in the light of the 3D model of the
first crystallized member of the family, the leucine
transporter LeuT.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Amino acid transport; CAATCH1; Cotransporters; Homology modelling; KAAT1; SLC6/NSS family
Elenco autori:
M. Castagna, E. Bossi, V.F. Sacchi
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